p35 Is Required for CDK5 Activation in Cellular Senescence

The retinoblastoma tumor suppressor gene (RB-1) is a key regulator of cellular senescence. Expression of the retinoblastoma protein (pRB) in human tumor cells that lack it results in senescence-like changes. The induction of the senescent phenotype by pRB requires the postmitotic kinase CDK5, the be...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2010-05, Vol.285 (19), p.14671-14680
Hauptverfasser:	Mao, Daqin, Hinds, Philip W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Blotting, Western Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell Biology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Differentiation Cell/Cycle Cell/Senescence Cells, Cultured Cellular Senescence Cyclin-Dependent Kinase 5 - genetics Cyclin-Dependent Kinase 5 - metabolism Diseases/Cancer Enzymes/Kinase Fibroblasts - metabolism Fluorescent Antibody Technique Humans Immunoprecipitation Molecular Bases of Disease Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Synaptotagmin I - genetics Synaptotagmin I - metabolism Transcription/Target Genes Tumor/Suppressor/Rb
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!