A Novel Wilms Tumor 1 (WT1) Target Gene Negatively Regulates the WNT Signaling Pathway

Mammalian kidney development requires the functions of the Wilms tumor gene WT1 and the WNT/β-catenin signaling pathway. Recent studies have shown that WT1 negatively regulates WNT/β-catenin signaling, but the molecular mechanisms by which WT1 inhibits WNT/β-catenin signaling are not completely unde...

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Veröffentlicht in:	The Journal of biological chemistry 2010-05, Vol.285 (19), p.14585-14593
Hauptverfasser:	Kim, Myoung Shin, Yoon, Seung Kew, Bollig, Frank, Kitagaki, Jirouta, Hur, Wonhee, Whye, Nathan J., Wu, Yun-Ping, Rivera, Miguel N., Park, Jik Young, Kim, Ho-Shik, Malik, Karim, Bell, Daphne W., Englert, Christoph, Perantoni, Alan O., Lee, Sean Bong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Axin Protein beta Catenin - genetics beta Catenin - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Chromatin Immunoprecipitation Danio rerio Developmental Biology Dishevelled Proteins DNA-Binding Proteins Down-Regulation Embryo, Nonmammalian - cytology Embryo, Nonmammalian - metabolism Gene Expression Gene Expression Regulation, Neoplastic Humans Immunoblotting Immunoglobulin G - immunology Immunoprecipitation Kidney Kidney - cytology Kidney - metabolism Luciferases - metabolism Mice NIH 3T3 Cells Phosphoproteins - genetics Phosphoproteins - metabolism Promoter Regions, Genetic Rabbits Repressor Proteins - genetics Repressor Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - pharmacology Signal Transduction Transcription Factors Transcription Target Genes Tumor Suppressor Wnt Pathway Wnt Proteins - genetics Wnt Proteins - metabolism WT1 Proteins - genetics WT1 Proteins - metabolism Zebrafish
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