Advantages of dynamic “closed loop” stable isotope flux phenotyping over static “open loop” clamps in detecting silent genetic and dietary phenotypes

In vivo insulin sensitivity can be assessed using “open loop” clamp or “closed loop” methods. Open loop clamp methods are static, and fix plasma glucose independently from plasma insulin. Closed loop methods are dynamic, and assess glucose disposal in response to a stable isotope labeled glucose tol...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Metabolomics 2010-06, Vol.6 (2), p.180-190
Hauptverfasser:	Vaitheesvaran, Bhavapriya, Chueh, Fu-Yu, Xu, Jun, Trujillo, Chuck, Saad, M. F, Lee, W. N. P, McGuinness, Owen P, Kurland, Irwin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Developmental Biology Life Sciences Metabolic flexibility Molecular Medicine Original Original Article Orphan nuclear receptor action Stable isotope flux phenotyping
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!