Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

Prostate cancer remains a leading cause of cancer death, as there are no durable means to treat advanced disease. Treatment of non-organ-confined prostate cancer hinges on its androgen dependence. First-line therapeutic strategies suppress androgen receptor (AR) activity, via androgen ablation and d...

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Veröffentlicht in:	Trends in endocrinology and metabolism 2010-05, Vol.21 (5), p.315-324
Hauptverfasser:	Knudsen, Karen E, Penning, Trevor M
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - therapeutic use Androgens - biosynthesis Biological and medical sciences Castration Endocrinology & Metabolism Fundamental and applied biological sciences. Psychology Gynecology. Andrology. Obstetrics Humans Male Male genital diseases Medical sciences Nephrology. Urinary tract diseases Prostate - metabolism Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Prostatic Neoplasms - physiopathology Receptors, Androgen - drug effects Receptors, Androgen - physiology Tumors Tumors of the urinary system Urinary tract. Prostate gland Vertebrates: endocrinology
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