Paclitaxel enhances early dendritic cell maturation and function through TLR4 signaling in mice

Subclinical doses of Paclitaxel (PTX) given 1 day prior to a HER-2/ neu (neu)-targeted, granulocyte–macrophage colony stimulating factor (GM-CSF)-secreting whole-cell vaccine enhances neu-specific T cell responses and slows neu + tumor growth in tolerized HER-2/ neu ( neu-N) mice. We demonstrate tha...

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Veröffentlicht in:	Cellular immunology 2010, Vol.263 (1), p.79-87
Hauptverfasser:	Pfannenstiel, Lukas W., Lam, Samuel S.K., Emens, Leisha A., Jaffee, Elizabeth M., Armstrong, Todd D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - biosynthesis Antigens, Neoplasm - immunology Cancer Vaccines CD8 antigen CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Differentiation - drug effects Cell Line, Tumor Chemotherapy, Adjuvant Combination therapy Cross-presentation Cyclophosphamide Cyclophosphamide - administration & dosage Cyclophosphamide - pharmacology Cytokines - genetics Cytokines - metabolism Cytotoxicity, Immunologic - drug effects Dendritic cell Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - pathology Drug Therapy, Combination Granulocyte-Macrophage Colony-Stimulating Factor - immunology Immunomodulation Immunotherapy Lymphocyte Activation - drug effects Mice Mice, Transgenic Neoplasm Transplantation Neoplasms - immunology Neoplasms - therapy Paclitaxel Paclitaxel - pharmacology Receptor, ErbB-2 - immunology Signal Transduction - drug effects Toll-Like Receptor 4 - metabolism Tumor Burden - drug effects
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