Single-molecule imaging brings Rad51 nucleoprotein filaments into focus

The Rad51 protein is essential for DNA repair by homologous recombination. After DNA damage, Rad51 localizes to nuclear foci that represent sites of DNA repair in vivo. In vitro , Rad51 self-assembles on single- or double-stranded DNA to form a nucleoprotein filament. Recently, the merging of innova...

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Veröffentlicht in:	Trends in cell biology 2010-05, Vol.20 (5), p.269-276
Hauptverfasser:	Forget, Anthony L, Kowalczykowski, Stephen C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA - genetics DNA - metabolism DNA Repair DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism Humans Nucleoproteins - metabolism Optical Tweezers Pathology Protein Binding Rad51 Recombinase - metabolism Recombination, Genetic
Online-Zugang:	Volltext
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