Phage WO of Wolbachia : lambda of the endosymbiont world
The discovery of an extraordinarily high level of mobile elements in the genome of Wolbachia , a widespread arthropod and nematode endosymbiont, suggests that this bacterium could be an excellent model for assessing the evolution and function of mobile DNA in specialized bacteria. In this paper, we...
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| Veröffentlicht in: | Trends in microbiology (Regular ed.) 2010-04, Vol.18 (4), p.173-181 |
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| creator | Kent, Bethany N Bordenstein, Seth R |
| description | The discovery of an extraordinarily high level of mobile elements in the genome of Wolbachia , a widespread arthropod and nematode endosymbiont, suggests that this bacterium could be an excellent model for assessing the evolution and function of mobile DNA in specialized bacteria. In this paper, we discuss how studies on the temperate bacteriophage WO of Wolbachia have revealed unexpected levels of genomic flux and are challenging previously held views about the clonality of obligate intracellular bacteria. We also discuss the roles this phage might play in the Wolbachia -arthropod symbiosis and infer how this research can be translated to combating human diseases vectored by arthropods. We expect that this temperate phage will be a preeminent model system to understand phage genetics, evolution and ecology in obligate intracellular bacteria. In this sense, phage WO might be likened to phage λ of the endosymbiont world. |
| doi_str_mv | 10.1016/j.tim.2009.12.011 |
| format | Article |
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| ispartof | Trends in microbiology (Regular ed.), 2010-04, Vol.18 (4), p.173-181 |
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| subjects | Animals Arthropoda Arthropods - microbiology Arthropods - physiology Bacteriophage lambda - genetics Bacteriophage lambda - physiology Bacteriophages - genetics Bacteriophages - physiology DNA Evolution, Molecular Internal Medicine Symbiosis Wolbachia - genetics Wolbachia - physiology Wolbachia - virology |
| title | Phage WO of Wolbachia : lambda of the endosymbiont world |
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