Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination
Abstract Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >...
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| Veröffentlicht in: | Vaccine 2010-05, Vol.28 (21), p.3672-3678 |
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| creator | Mehta, Nishaki Cunningham, Coleen K Flynn, Patricia Pepe, Joyce Obaro, Stephen Kapogiannis, Bill G Bethel, James Luzuriaga, Katherine |
| description | Abstract Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10 mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000 mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals. |
| doi_str_mv | 10.1016/j.vaccine.2010.03.022 |
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HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10 mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000 mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2010.03.022</identifier><identifier>PMID: 20356567</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Acquired immune deficiency syndrome ; Adolescence ; Adolescent ; AIDS ; Allergy and Immunology ; Applied microbiology ; B-Lymphocytes - immunology ; B-Lymphocytes - virology ; Biological and medical sciences ; Cell Proliferation ; Drug therapy ; Female ; Fundamental and applied biological sciences. Psychology ; Hepatitis ; Hepatitis B - complications ; Hepatitis B - immunology ; Hepatitis B Antibodies - blood ; Hepatitis B Surface Antigens - immunology ; Hepatitis B vaccines ; Hepatitis B Vaccines - immunology ; HIV ; HIV Infections - complications ; HIV Infections - immunology ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Immunization ; Immunologic Memory - immunology ; Infectious diseases ; Longitudinal Studies ; Male ; Medical sciences ; Memory B cells ; Microbiology ; Miscellaneous ; Studies ; Teenagers ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Virology ; Young Adult</subject><ispartof>Vaccine, 2010-05, Vol.28 (21), p.3672-3678</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Elsevier Limited May 7, 2010</rights><rights>2010 Elsevier Ltd. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-9d24e9a1f335d4193dfbd6576d5f986816c859cf15e0e91f792298442ff189333</citedby><cites>FETCH-LOGICAL-c611t-9d24e9a1f335d4193dfbd6576d5f986816c859cf15e0e91f792298442ff189333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X10003580$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22744767$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20356567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehta, Nishaki</creatorcontrib><creatorcontrib>Cunningham, Coleen K</creatorcontrib><creatorcontrib>Flynn, Patricia</creatorcontrib><creatorcontrib>Pepe, Joyce</creatorcontrib><creatorcontrib>Obaro, Stephen</creatorcontrib><creatorcontrib>Kapogiannis, Bill G</creatorcontrib><creatorcontrib>Bethel, James</creatorcontrib><creatorcontrib>Luzuriaga, Katherine</creatorcontrib><creatorcontrib>Adolescent Trials Network for HIV/AIDS Interventions</creatorcontrib><title>Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10 mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000 mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adolescence</subject><subject>Adolescent</subject><subject>AIDS</subject><subject>Allergy and Immunology</subject><subject>Applied microbiology</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - virology</subject><subject>Biological and medical sciences</subject><subject>Cell Proliferation</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hepatitis</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis B Antibodies - blood</subject><subject>Hepatitis B Surface Antigens - immunology</subject><subject>Hepatitis B vaccines</subject><subject>Hepatitis B Vaccines - immunology</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - immunology</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunologic Memory - immunology</subject><subject>Infectious diseases</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory B cells</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Studies</subject><subject>Teenagers</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10 mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000 mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20356567</pmid><doi>10.1016/j.vaccine.2010.03.022</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acquired immune deficiency syndrome Adolescence Adolescent AIDS Allergy and Immunology Applied microbiology B-Lymphocytes - immunology B-Lymphocytes - virology Biological and medical sciences Cell Proliferation Drug therapy Female Fundamental and applied biological sciences. Psychology Hepatitis Hepatitis B - complications Hepatitis B - immunology Hepatitis B Antibodies - blood Hepatitis B Surface Antigens - immunology Hepatitis B vaccines Hepatitis B Vaccines - immunology HIV HIV Infections - complications HIV Infections - immunology Human immunodeficiency virus Human viral diseases Humans Immunization Immunologic Memory - immunology Infectious diseases Longitudinal Studies Male Medical sciences Memory B cells Microbiology Miscellaneous Studies Teenagers Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology Young Adult |
| title | Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination |
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