Expression levels of TRPC1 and TRPC6 ion channels are reciprocally altered in aging rat aorta: implications for age-related vasospastic disorders

We previously showed that the expression of transient receptor potential canonical (TRPC)6 ion channel elevated when TRPC1 was knocked down in A7r5 cultured vascular smooth muscle cells. Therefore, the purpose of this study was to explore whether TRPC6 is also upregulated in aging rat aorta comparab...

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Veröffentlicht in:	AGE 2010-06, Vol.32 (2), p.223-230
Hauptverfasser:	Erac, Yasemin, Selli, Cigdem, Kosova, Buket, Akcali, Kamil C, Tosun, Metiner
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adrenergic receptors Age Age Factors Aging Aging - physiology Animals Aorta - metabolism Aorta - physiopathology Biomedical and Life Sciences Blotting, Western Cardiovascular disease Cell Biology Coronary Vasospasm - genetics Coronary Vasospasm - physiopathology Coronary vessels DNA Primers - genetics DNA, Complementary - biosynthesis Endothelium Geriatrics/Gerontology Laboratory animals Life Sciences Male Molecular Medicine Muscle, Smooth - metabolism Muscle, Smooth - physiopathology Proteins Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Smooth muscle Transient receptor potential TRPC TRPC Cation Channels - genetics Vascular smooth muscle
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