Spatial Configuration of Transposable Element Ac Termini Affects Their Ability to Induce Chromosomal Breakage in Maize
Composite or closely linked maize (Zea mays) Ac/Ds transposable elements can induce chromosome breakage, but the precise configurations of Ac/Ds elements that can lead to chromosome breakage are not completely defined. Here, we determined the structures and chromosome breakage properties of 15 maize...
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| Veröffentlicht in: | The Plant cell 2010-03, Vol.22 (3), p.744-754 |
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| creator | Yu, Chuanhe Zhang, Jianbo Pulletikurti, Vinay Weber, David F Peterson, Thomas |
| description | Composite or closely linked maize (Zea mays) Ac/Ds transposable elements can induce chromosome breakage, but the precise configurations of Ac/Ds elements that can lead to chromosome breakage are not completely defined. Here, we determined the structures and chromosome breakage properties of 15 maize p1 alleles: each allele contains a fixed fractured Ac (fAc) element and a closely linked full-length Ac at various flanking sites. Our results show that pairs of Ac/fAc elements in which the termini of different elements are in direct or reverse orientation can induce chromosome breakage. By contrast, no chromosome breakage is observed with alleles containing pairs of Ac/fAc elements in which the external termini of the paired elements can function as a macrotransposon. Among the structures that can lead to chromosome breaks, breakage frequency is inversely correlated with the distance between the interacting Ac/Ds termini. These results provide new insight into the mechanism of transposition-induced chromosome breakage, which is one outcome of the chromosome-restructuring ability of alternative transposition events. |
| doi_str_mv | 10.1105/tpc.109.070052 |
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Here, we determined the structures and chromosome breakage properties of 15 maize p1 alleles: each allele contains a fixed fractured Ac (fAc) element and a closely linked full-length Ac at various flanking sites. Our results show that pairs of Ac/fAc elements in which the termini of different elements are in direct or reverse orientation can induce chromosome breakage. By contrast, no chromosome breakage is observed with alleles containing pairs of Ac/fAc elements in which the external termini of the paired elements can function as a macrotransposon. Among the structures that can lead to chromosome breaks, breakage frequency is inversely correlated with the distance between the interacting Ac/Ds termini. These results provide new insight into the mechanism of transposition-induced chromosome breakage, which is one outcome of the chromosome-restructuring ability of alternative transposition events.</description><identifier>ISSN: 1040-4651</identifier><identifier>EISSN: 1532-298X</identifier><identifier>DOI: 10.1105/tpc.109.070052</identifier><identifier>PMID: 20228246</identifier><language>eng</language><publisher>United States: American Society of Plant Biologists</publisher><subject>Alleles ; Chromatids ; Chromosome Breakage ; Chromosomes ; Chromosomes, Plant - genetics ; Corn ; DNA Transposable Elements ; DNA, Plant - genetics ; Genes ; Genetic loci ; Genetic transposition ; Mutagenesis, Insertional ; Polymerase chain reaction ; Transposons ; Zea mays - genetics</subject><ispartof>The Plant cell, 2010-03, Vol.22 (3), p.744-754</ispartof><rights>2010 American Society of Plant Biologists</rights><rights>Copyright American Society of Plant Biologists Mar 2010</rights><rights>2010 American Society of Plant Biologists 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-670ca4b9dff479323f764da1454531a757c84c53a92cee7cb588d17e9a0df1953</citedby><cites>FETCH-LOGICAL-c422t-670ca4b9dff479323f764da1454531a757c84c53a92cee7cb588d17e9a0df1953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25680090$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25680090$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,777,781,800,882,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20228246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Chuanhe</creatorcontrib><creatorcontrib>Zhang, Jianbo</creatorcontrib><creatorcontrib>Pulletikurti, Vinay</creatorcontrib><creatorcontrib>Weber, David F</creatorcontrib><creatorcontrib>Peterson, Thomas</creatorcontrib><title>Spatial Configuration of Transposable Element Ac Termini Affects Their Ability to Induce Chromosomal Breakage in Maize</title><title>The Plant cell</title><addtitle>Plant Cell</addtitle><description>Composite or closely linked maize (Zea mays) Ac/Ds transposable elements can induce chromosome breakage, but the precise configurations of Ac/Ds elements that can lead to chromosome breakage are not completely defined. Here, we determined the structures and chromosome breakage properties of 15 maize p1 alleles: each allele contains a fixed fractured Ac (fAc) element and a closely linked full-length Ac at various flanking sites. Our results show that pairs of Ac/fAc elements in which the termini of different elements are in direct or reverse orientation can induce chromosome breakage. By contrast, no chromosome breakage is observed with alleles containing pairs of Ac/fAc elements in which the external termini of the paired elements can function as a macrotransposon. Among the structures that can lead to chromosome breaks, breakage frequency is inversely correlated with the distance between the interacting Ac/Ds termini. These results provide new insight into the mechanism of transposition-induced chromosome breakage, which is one outcome of the chromosome-restructuring ability of alternative transposition events.</description><subject>Alleles</subject><subject>Chromatids</subject><subject>Chromosome Breakage</subject><subject>Chromosomes</subject><subject>Chromosomes, Plant - genetics</subject><subject>Corn</subject><subject>DNA Transposable Elements</subject><subject>DNA, Plant - genetics</subject><subject>Genes</subject><subject>Genetic loci</subject><subject>Genetic transposition</subject><subject>Mutagenesis, Insertional</subject><subject>Polymerase chain reaction</subject><subject>Transposons</subject><subject>Zea mays - genetics</subject><issn>1040-4651</issn><issn>1532-298X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkUtv1DAUhSMEoqWwZQdYbFhluH7F8QZpGBWoVMSiU4md5Tj2jIckTu2kUvvra0gpj5WvdT4f36NTFC8xrDAG_n4azQqDXIEA4ORRcYw5JSWR9ffHeQYGJas4PiqepXQAACywfFocESCkJqw6Lq4vRj153aFNGJzfzTHfwoCCQ9uohzSGpJvOotPO9naY0NqgrY29HzxaO2fNlNB2b31E68Z3frpBU0BnQzsbizb7GPqQQp_NP0arf-idRX5AX7W_tc-LJ053yb64P0-Ky0-n282X8vzb57PN-rw0jJCprAQYzRrZOseEpIQ6UbFWY8YZp1gLLkzNDKdaEmOtMA2v6xYLKzW0DktOT4oPi-84N71tTc4QdafG6Hsdb1TQXv2rDH6vduFakbrKv1TZ4N29QQxXs02T6n0ytuv0YMOclKCUS1pLyOTb_8hDmOOQ0ymCayEJMJGh1QKZGFKK1j2sgkH9LFTlQvMs1VJofvD67wAP-O8GM_BqAQ5pCvGPzqsa4Ndabxbd6aD0LvqkLi8IYAq4plhWlN4BrwSwHg</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Yu, Chuanhe</creator><creator>Zhang, Jianbo</creator><creator>Pulletikurti, Vinay</creator><creator>Weber, David F</creator><creator>Peterson, Thomas</creator><general>American Society of Plant Biologists</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QO</scope><scope>7TM</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100301</creationdate><title>Spatial Configuration of Transposable Element Ac Termini Affects Their Ability to Induce Chromosomal Breakage in Maize</title><author>Yu, Chuanhe ; Zhang, Jianbo ; Pulletikurti, Vinay ; Weber, David F ; Peterson, Thomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-670ca4b9dff479323f764da1454531a757c84c53a92cee7cb588d17e9a0df1953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Alleles</topic><topic>Chromatids</topic><topic>Chromosome Breakage</topic><topic>Chromosomes</topic><topic>Chromosomes, Plant - genetics</topic><topic>Corn</topic><topic>DNA Transposable Elements</topic><topic>DNA, Plant - genetics</topic><topic>Genes</topic><topic>Genetic loci</topic><topic>Genetic transposition</topic><topic>Mutagenesis, Insertional</topic><topic>Polymerase chain reaction</topic><topic>Transposons</topic><topic>Zea mays - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Chuanhe</creatorcontrib><creatorcontrib>Zhang, Jianbo</creatorcontrib><creatorcontrib>Pulletikurti, Vinay</creatorcontrib><creatorcontrib>Weber, David F</creatorcontrib><creatorcontrib>Peterson, Thomas</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Plant cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Chuanhe</au><au>Zhang, Jianbo</au><au>Pulletikurti, Vinay</au><au>Weber, David F</au><au>Peterson, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spatial Configuration of Transposable Element Ac Termini Affects Their Ability to Induce Chromosomal Breakage in Maize</atitle><jtitle>The Plant cell</jtitle><addtitle>Plant Cell</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>22</volume><issue>3</issue><spage>744</spage><epage>754</epage><pages>744-754</pages><issn>1040-4651</issn><eissn>1532-298X</eissn><abstract>Composite or closely linked maize (Zea mays) Ac/Ds transposable elements can induce chromosome breakage, but the precise configurations of Ac/Ds elements that can lead to chromosome breakage are not completely defined. Here, we determined the structures and chromosome breakage properties of 15 maize p1 alleles: each allele contains a fixed fractured Ac (fAc) element and a closely linked full-length Ac at various flanking sites. Our results show that pairs of Ac/fAc elements in which the termini of different elements are in direct or reverse orientation can induce chromosome breakage. By contrast, no chromosome breakage is observed with alleles containing pairs of Ac/fAc elements in which the external termini of the paired elements can function as a macrotransposon. Among the structures that can lead to chromosome breaks, breakage frequency is inversely correlated with the distance between the interacting Ac/Ds termini. These results provide new insight into the mechanism of transposition-induced chromosome breakage, which is one outcome of the chromosome-restructuring ability of alternative transposition events.</abstract><cop>United States</cop><pub>American Society of Plant Biologists</pub><pmid>20228246</pmid><doi>10.1105/tpc.109.070052</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Alleles Chromatids Chromosome Breakage Chromosomes Chromosomes, Plant - genetics Corn DNA Transposable Elements DNA, Plant - genetics Genes Genetic loci Genetic transposition Mutagenesis, Insertional Polymerase chain reaction Transposons Zea mays - genetics |
| title | Spatial Configuration of Transposable Element Ac Termini Affects Their Ability to Induce Chromosomal Breakage in Maize |
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