Epicardium and Myocardium Separate From a Common Precursor Pool by Crosstalk Between Bone Morphogenetic Protein– and Fibroblast Growth Factor–Signaling Pathways

RATIONALE:The epicardium contributes to the majority of nonmyocardial cells in the adult heart. Recent studies have reported that the epicardium is derived from Nkx2.5-positive progenitors and can differentiate into cardiomyocytes. Not much is known about the relation between the myocardial and epic...

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Veröffentlicht in:	Circulation research 2009-08, Vol.105 (5), p.431-441
Hauptverfasser:	van Wijk, Bram, van den Berg, Gert, Abu-Issa, Radwan, Barnett, Phil, van der Velden, Saskia, Schmidt, Martina, Ruijter, Jan M, Kirby, Margaret L, Moorman, Antoon F.M, van den Hoff, Maurice J.B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Bone Morphogenetic Protein 2 - metabolism Bone Morphogenetic Proteins - metabolism Butadienes - pharmacology Carbocyanines Cell Differentiation Cell Line Cell Lineage - drug effects Cell Lineage - genetics Cell Proliferation Chick Embryo Extracellular Signal-Regulated MAP Kinases - metabolism Fibroblast Growth Factor 2 - metabolism Fibroblast Growth Factors - metabolism Fluorescent Dyes Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Heart - drug effects Heart - embryology Image Processing, Computer-Assisted Imaging, Three-Dimensional MAP Kinase Kinase 1 - antagonists & inhibitors MAP Kinase Kinase 1 - metabolism MAP Kinase Kinase 2 - antagonists & inhibitors MAP Kinase Kinase 2 - metabolism Microscopy, Fluorescence Myocardium - metabolism Nitriles - pharmacology Pericardium - drug effects Pericardium - embryology Pericardium - metabolism Phenotype Phosphorylation Protein Kinase Inhibitors - pharmacology Rats Recombinant Proteins - metabolism Signal Transduction - drug effects Signal Transduction - genetics Smad Proteins - metabolism T-Box Domain Proteins - genetics Vertebrates: cardiovascular system
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