Antibody-Directed Myostatin Inhibition Improves Diaphragm Pathology in Young but not Adult Dystrophic mdx Mice

Duchenne muscular dystrophy (DMD) is characterized by progressive skeletal muscle wasting and weakness, leading to premature death from respiratory and/or cardiac failure. A clinically relevant question is whether myostatin inhibition can improve function of the diaphragm, which exhibits a severe an...

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Veröffentlicht in:	The American journal of pathology 2010-05, Vol.176 (5), p.2425-2434
Hauptverfasser:	Murphy, Kate T, Ryall, James G, Snell, Sarah M, Nair, Lawrence, Koopman, René, Krasney, Philip A, Ibebunjo, Chikwendu, Holden, Kathryn S, Loria, Paula M, Salatto, Christopher T, Lynch, Gordon S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Biological and medical sciences Diaphragm - pathology Inhibitory Concentration 50 Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred mdx Muscle Contraction Muscle Fibers, Skeletal - pathology Muscular Dystrophy, Animal - metabolism Muscular Dystrophy, Animal - pathology Myostatin - antagonists & inhibitors Myostatin - chemistry Myostatin - metabolism Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Regular Time Factors
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