Glutathione S‐transferase polymorphisms are associated with survival in anaplastic glioma patients
BACKGROUND: Glutathione S‐transferases (GSTs) are polymorphic enzymes that are responsible for glutathione conjugation of alkylators and scavenging of free radicals created by radiation. GST polymorphisms may result in altered or absent enzyme activity and have been associated with survival in patie...
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| creator | Kilburn, Lindsay Okcu, M. Fatih Wang, Tao Cao, Yumei Renfro‐Spelman, Amy Aldape, Kenneth D. Gilbert, Mark R. Bondy, Melissa |
| description | BACKGROUND:
Glutathione S‐transferases (GSTs) are polymorphic enzymes that are responsible for glutathione conjugation of alkylators and scavenging of free radicals created by radiation. GST polymorphisms may result in altered or absent enzyme activity and have been associated with survival in patients with cancer. The authors of this report hypothesized that patients with anaplastic glioma (AG) who have GST genotypes that encode for lower activity enzymes will have longer survival than similar patients who have higher activity genotypes. The current study was performed to investigate the role of GST enzyme polymorphisms in predicting the survival of patients with AG.
METHODS:
The medical records of 207 patients with AG from a single cancer center were reviewed retrospectively. Polymorphisms for the GST μ1 (GSTM1), GST θ1 (GSTT1), and GST π1 (GSTP1) enzymes were identified. Overall survival was compared using the Kaplan‐Meier method and Cox proportional hazards analyses adjusting for age, sex, histology, and therapy.
RESULTS:
Among the patients with oligodendroglial tumors (n = 94), patients who had the GSTT1 null genotype had a 2.9 times increased risk of death (95% confidence interval [CI], 1.3‐6.3) compared with patients who had the GSTT1 non‐null genotype. Adjustment for 1p/19q status did not change the finding. In the patients who had anaplastic astrocytoma (n = 113), the patients with all GSTP1 genotypes except GSTP1 *B/*B had a 3.8 times increased risk of death (95% CI, 0.5‐29.6) compared with patients who had the GSTP1 *B/*B genotype.
CONCLUSIONS:
In patients with anaplastic oligodendroglial tumors, the GSTT1 null genotype may be associated with poor survival, possibly because of modifications in therapy secondary to increased toxicity. This hypothesis is under investigation. In patients with anaplastic astrocytoma, the GSTP1 *B/*B genotype may confer a survival advantage. Cancer 2010. © 2010 American Cancer Society.
Glutathione S‐transferase polymorphisms are associated with survival in patients with anaplastic glial brain tumors. |
| doi_str_mv | 10.1002/cncr.25006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2861043</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1238121880</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5156-d63825dd3287c9098ba6edab32130235eb703990ee5614f6337f54ed053475d3</originalsourceid><addsrcrecordid>eNqFkcGKFDEQhoMo7rh68QEkF0GEXitJpzt9EZZBV2FR0D14CzXp9E4k3WlTPbPMzUfwGX0Se5xx1YueilAf_1_hY-yxgDMBIF-4weUzqQGqO2whoKkLEKW8yxYAYApdqk8n7AHR5_lZS63usxMJwtTQVAvWXsTNhNM6pMHzj9-_fpsyDtT5jOT5mOKuT3lcB-qJY_YciZILOPmW34RpzWmTt2GLkYeB44BjRJqC49cxpB75iFPww0QP2b0OI_lHx3nKrl6_ulq-KS7fX7xdnl8WTgtdFW2ljNRtq6SpXQONWWHlW1wpKRRIpf2qBtU04L2uRNlVStWdLn0LWpW1btUpe3mIHTer3rdurs4Y7ZhDj3lnEwb792YIa3udtlaaSkCp5oBnx4Ccvmw8TbYP5HyMOPi0ISukMkIKY-D_KIi6qYxq9Iw-P6AuJ6Lsu9uLBNi9QLsXaH8KnOEnf_7hFv1lbAaeHgEkh7GbdblAvzlZz9LF_kBx4G5C9Lt_VNrlu-WHQ_kPZMa1sw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1017968395</pqid></control><display><type>article</type><title>Glutathione S‐transferase polymorphisms are associated with survival in anaplastic glioma patients</title><source>MEDLINE</source><source>Wiley Journals</source><source>Wiley Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Kilburn, Lindsay ; Okcu, M. Fatih ; Wang, Tao ; Cao, Yumei ; Renfro‐Spelman, Amy ; Aldape, Kenneth D. ; Gilbert, Mark R. ; Bondy, Melissa</creator><creatorcontrib>Kilburn, Lindsay ; Okcu, M. Fatih ; Wang, Tao ; Cao, Yumei ; Renfro‐Spelman, Amy ; Aldape, Kenneth D. ; Gilbert, Mark R. ; Bondy, Melissa</creatorcontrib><description>BACKGROUND:
Glutathione S‐transferases (GSTs) are polymorphic enzymes that are responsible for glutathione conjugation of alkylators and scavenging of free radicals created by radiation. GST polymorphisms may result in altered or absent enzyme activity and have been associated with survival in patients with cancer. The authors of this report hypothesized that patients with anaplastic glioma (AG) who have GST genotypes that encode for lower activity enzymes will have longer survival than similar patients who have higher activity genotypes. The current study was performed to investigate the role of GST enzyme polymorphisms in predicting the survival of patients with AG.
METHODS:
The medical records of 207 patients with AG from a single cancer center were reviewed retrospectively. Polymorphisms for the GST μ1 (GSTM1), GST θ1 (GSTT1), and GST π1 (GSTP1) enzymes were identified. Overall survival was compared using the Kaplan‐Meier method and Cox proportional hazards analyses adjusting for age, sex, histology, and therapy.
RESULTS:
Among the patients with oligodendroglial tumors (n = 94), patients who had the GSTT1 null genotype had a 2.9 times increased risk of death (95% confidence interval [CI], 1.3‐6.3) compared with patients who had the GSTT1 non‐null genotype. Adjustment for 1p/19q status did not change the finding. In the patients who had anaplastic astrocytoma (n = 113), the patients with all GSTP1 genotypes except GSTP1 *B/*B had a 3.8 times increased risk of death (95% CI, 0.5‐29.6) compared with patients who had the GSTP1 *B/*B genotype.
CONCLUSIONS:
In patients with anaplastic oligodendroglial tumors, the GSTT1 null genotype may be associated with poor survival, possibly because of modifications in therapy secondary to increased toxicity. This hypothesis is under investigation. In patients with anaplastic astrocytoma, the GSTP1 *B/*B genotype may confer a survival advantage. Cancer 2010. © 2010 American Cancer Society.
Glutathione S‐transferase polymorphisms are associated with survival in patients with anaplastic glial brain tumors.</description><identifier>ISSN: 0008-543X</identifier><identifier>ISSN: 1097-0142</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.25006</identifier><identifier>PMID: 20187096</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; anaplastic glioma ; Biological and medical sciences ; Brain Neoplasms - genetics ; Brain Neoplasms - mortality ; Cancer ; Enzymes ; Female ; Genotype ; Genotypes ; glioma ; Glioma - genetics ; Glioma - mortality ; glutathione S‐transferase polymorphisms ; Glutathione Transferase - genetics ; Histology ; Humans ; Male ; Medical sciences ; Middle Aged ; Mortality ; Neurology ; Oligodendroglioma - genetics ; Oligodendroglioma - mortality ; pharmacogenetics ; Polymorphism, Genetic ; Proportional Hazards Models ; survival ; Toxicity ; Tumors ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Cancer, 2010-05, Vol.116 (9), p.2242-2249</ispartof><rights>Copyright © 2010 American Cancer Society</rights><rights>2015 INIST-CNRS</rights><rights>(c) 2010 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5156-d63825dd3287c9098ba6edab32130235eb703990ee5614f6337f54ed053475d3</citedby><cites>FETCH-LOGICAL-c5156-d63825dd3287c9098ba6edab32130235eb703990ee5614f6337f54ed053475d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.25006$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.25006$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22700810$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20187096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kilburn, Lindsay</creatorcontrib><creatorcontrib>Okcu, M. Fatih</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Cao, Yumei</creatorcontrib><creatorcontrib>Renfro‐Spelman, Amy</creatorcontrib><creatorcontrib>Aldape, Kenneth D.</creatorcontrib><creatorcontrib>Gilbert, Mark R.</creatorcontrib><creatorcontrib>Bondy, Melissa</creatorcontrib><title>Glutathione S‐transferase polymorphisms are associated with survival in anaplastic glioma patients</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND:
Glutathione S‐transferases (GSTs) are polymorphic enzymes that are responsible for glutathione conjugation of alkylators and scavenging of free radicals created by radiation. GST polymorphisms may result in altered or absent enzyme activity and have been associated with survival in patients with cancer. The authors of this report hypothesized that patients with anaplastic glioma (AG) who have GST genotypes that encode for lower activity enzymes will have longer survival than similar patients who have higher activity genotypes. The current study was performed to investigate the role of GST enzyme polymorphisms in predicting the survival of patients with AG.
METHODS:
The medical records of 207 patients with AG from a single cancer center were reviewed retrospectively. Polymorphisms for the GST μ1 (GSTM1), GST θ1 (GSTT1), and GST π1 (GSTP1) enzymes were identified. Overall survival was compared using the Kaplan‐Meier method and Cox proportional hazards analyses adjusting for age, sex, histology, and therapy.
RESULTS:
Among the patients with oligodendroglial tumors (n = 94), patients who had the GSTT1 null genotype had a 2.9 times increased risk of death (95% confidence interval [CI], 1.3‐6.3) compared with patients who had the GSTT1 non‐null genotype. Adjustment for 1p/19q status did not change the finding. In the patients who had anaplastic astrocytoma (n = 113), the patients with all GSTP1 genotypes except GSTP1 *B/*B had a 3.8 times increased risk of death (95% CI, 0.5‐29.6) compared with patients who had the GSTP1 *B/*B genotype.
CONCLUSIONS:
In patients with anaplastic oligodendroglial tumors, the GSTT1 null genotype may be associated with poor survival, possibly because of modifications in therapy secondary to increased toxicity. This hypothesis is under investigation. In patients with anaplastic astrocytoma, the GSTP1 *B/*B genotype may confer a survival advantage. Cancer 2010. © 2010 American Cancer Society.
Glutathione S‐transferase polymorphisms are associated with survival in patients with anaplastic glial brain tumors.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>anaplastic glioma</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - mortality</subject><subject>Cancer</subject><subject>Enzymes</subject><subject>Female</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>glioma</subject><subject>Glioma - genetics</subject><subject>Glioma - mortality</subject><subject>glutathione S‐transferase polymorphisms</subject><subject>Glutathione Transferase - genetics</subject><subject>Histology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neurology</subject><subject>Oligodendroglioma - genetics</subject><subject>Oligodendroglioma - mortality</subject><subject>pharmacogenetics</subject><subject>Polymorphism, Genetic</subject><subject>Proportional Hazards Models</subject><subject>survival</subject><subject>Toxicity</subject><subject>Tumors</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0008-543X</issn><issn>1097-0142</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGKFDEQhoMo7rh68QEkF0GEXitJpzt9EZZBV2FR0D14CzXp9E4k3WlTPbPMzUfwGX0Se5xx1YueilAf_1_hY-yxgDMBIF-4weUzqQGqO2whoKkLEKW8yxYAYApdqk8n7AHR5_lZS63usxMJwtTQVAvWXsTNhNM6pMHzj9-_fpsyDtT5jOT5mOKuT3lcB-qJY_YciZILOPmW34RpzWmTt2GLkYeB44BjRJqC49cxpB75iFPww0QP2b0OI_lHx3nKrl6_ulq-KS7fX7xdnl8WTgtdFW2ljNRtq6SpXQONWWHlW1wpKRRIpf2qBtU04L2uRNlVStWdLn0LWpW1btUpe3mIHTer3rdurs4Y7ZhDj3lnEwb792YIa3udtlaaSkCp5oBnx4Ccvmw8TbYP5HyMOPi0ISukMkIKY-D_KIi6qYxq9Iw-P6AuJ6Lsu9uLBNi9QLsXaH8KnOEnf_7hFv1lbAaeHgEkh7GbdblAvzlZz9LF_kBx4G5C9Lt_VNrlu-WHQ_kPZMa1sw</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Kilburn, Lindsay</creator><creator>Okcu, M. Fatih</creator><creator>Wang, Tao</creator><creator>Cao, Yumei</creator><creator>Renfro‐Spelman, Amy</creator><creator>Aldape, Kenneth D.</creator><creator>Gilbert, Mark R.</creator><creator>Bondy, Melissa</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20100501</creationdate><title>Glutathione S‐transferase polymorphisms are associated with survival in anaplastic glioma patients</title><author>Kilburn, Lindsay ; Okcu, M. Fatih ; Wang, Tao ; Cao, Yumei ; Renfro‐Spelman, Amy ; Aldape, Kenneth D. ; Gilbert, Mark R. ; Bondy, Melissa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5156-d63825dd3287c9098ba6edab32130235eb703990ee5614f6337f54ed053475d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>anaplastic glioma</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - mortality</topic><topic>Cancer</topic><topic>Enzymes</topic><topic>Female</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>glioma</topic><topic>Glioma - genetics</topic><topic>Glioma - mortality</topic><topic>glutathione S‐transferase polymorphisms</topic><topic>Glutathione Transferase - genetics</topic><topic>Histology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neurology</topic><topic>Oligodendroglioma - genetics</topic><topic>Oligodendroglioma - mortality</topic><topic>pharmacogenetics</topic><topic>Polymorphism, Genetic</topic><topic>Proportional Hazards Models</topic><topic>survival</topic><topic>Toxicity</topic><topic>Tumors</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kilburn, Lindsay</creatorcontrib><creatorcontrib>Okcu, M. Fatih</creatorcontrib><creatorcontrib>Wang, Tao</creatorcontrib><creatorcontrib>Cao, Yumei</creatorcontrib><creatorcontrib>Renfro‐Spelman, Amy</creatorcontrib><creatorcontrib>Aldape, Kenneth D.</creatorcontrib><creatorcontrib>Gilbert, Mark R.</creatorcontrib><creatorcontrib>Bondy, Melissa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kilburn, Lindsay</au><au>Okcu, M. Fatih</au><au>Wang, Tao</au><au>Cao, Yumei</au><au>Renfro‐Spelman, Amy</au><au>Aldape, Kenneth D.</au><au>Gilbert, Mark R.</au><au>Bondy, Melissa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione S‐transferase polymorphisms are associated with survival in anaplastic glioma patients</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2010-05-01</date><risdate>2010</risdate><volume>116</volume><issue>9</issue><spage>2242</spage><epage>2249</epage><pages>2242-2249</pages><issn>0008-543X</issn><issn>1097-0142</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND:
Glutathione S‐transferases (GSTs) are polymorphic enzymes that are responsible for glutathione conjugation of alkylators and scavenging of free radicals created by radiation. GST polymorphisms may result in altered or absent enzyme activity and have been associated with survival in patients with cancer. The authors of this report hypothesized that patients with anaplastic glioma (AG) who have GST genotypes that encode for lower activity enzymes will have longer survival than similar patients who have higher activity genotypes. The current study was performed to investigate the role of GST enzyme polymorphisms in predicting the survival of patients with AG.
METHODS:
The medical records of 207 patients with AG from a single cancer center were reviewed retrospectively. Polymorphisms for the GST μ1 (GSTM1), GST θ1 (GSTT1), and GST π1 (GSTP1) enzymes were identified. Overall survival was compared using the Kaplan‐Meier method and Cox proportional hazards analyses adjusting for age, sex, histology, and therapy.
RESULTS:
Among the patients with oligodendroglial tumors (n = 94), patients who had the GSTT1 null genotype had a 2.9 times increased risk of death (95% confidence interval [CI], 1.3‐6.3) compared with patients who had the GSTT1 non‐null genotype. Adjustment for 1p/19q status did not change the finding. In the patients who had anaplastic astrocytoma (n = 113), the patients with all GSTP1 genotypes except GSTP1 *B/*B had a 3.8 times increased risk of death (95% CI, 0.5‐29.6) compared with patients who had the GSTP1 *B/*B genotype.
CONCLUSIONS:
In patients with anaplastic oligodendroglial tumors, the GSTT1 null genotype may be associated with poor survival, possibly because of modifications in therapy secondary to increased toxicity. This hypothesis is under investigation. In patients with anaplastic astrocytoma, the GSTP1 *B/*B genotype may confer a survival advantage. Cancer 2010. © 2010 American Cancer Society.
Glutathione S‐transferase polymorphisms are associated with survival in patients with anaplastic glial brain tumors.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20187096</pmid><doi>10.1002/cncr.25006</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged anaplastic glioma Biological and medical sciences Brain Neoplasms - genetics Brain Neoplasms - mortality Cancer Enzymes Female Genotype Genotypes glioma Glioma - genetics Glioma - mortality glutathione S‐transferase polymorphisms Glutathione Transferase - genetics Histology Humans Male Medical sciences Middle Aged Mortality Neurology Oligodendroglioma - genetics Oligodendroglioma - mortality pharmacogenetics Polymorphism, Genetic Proportional Hazards Models survival Toxicity Tumors Tumors of the nervous system. Phacomatoses |
| title | Glutathione S‐transferase polymorphisms are associated with survival in anaplastic glioma patients |
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