Optimization of a Reusable, DNA Pseudoknot-Based Electrochemical Sensor for Sequence-Specific DNA Detection in Blood Serum

We describe in detail a new electrochemical DNA (E-DNA) sensing platform based on target-induced conformation changes in an electrode-bound DNA pseudoknot. The pseudoknot, a DNA structure containing two stem-loops in which the first stem’s loop forms part of the second stem, is modified with a methy...

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Veröffentlicht in:	Analytical chemistry (Washington) 2009-01, Vol.81 (2), p.656-661
Hauptverfasser:	Cash, Kevin J, Heeger, Alan J, Plaxco, Kevin W, Xiao, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Base Sequence Biosensing Techniques Blood Chemistry Deoxyribonucleic acid DNA DNA - blood DNA - chemistry Electrocatalysis Electrochemical methods Electrochemistry Electrodes Electrons Exact sciences and technology General, instrumentation Gold - chemistry Molecular structure Parameter optimization
Online-Zugang:	Volltext
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