Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents

The transient receptor potential vanilloid 1 (TRPV1) channel is the principal detector of noxious heat in the peripheral nervous system. TRPV1 is expressed in many nociceptors and is involved in heat-induced hyperalgesia and thermoregulation. The precise mechanism or mechanisms mediating the thermal...

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Veröffentlicht in:	The Journal of clinical investigation 2010-05, Vol.120 (5), p.1617-1626
Hauptverfasser:	Patwardhan, Amol M, Akopian, Armen N, Ruparel, Nikita B, Diogenes, Anibal, Weintraub, Susan T, Uhlson, Charis, Murphy, Robert C, Hargreaves, Kenneth M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Analgesia Animals Biomedical research Biopsy Fatty Acids, Unsaturated - metabolism Health aspects Heat Hot Temperature Hyperalgesia Ligands Linoleic Acid - metabolism Linoleic acids Male Metabolites Mice Mice, Inbred C57BL Models, Biological Neurons Oxygen - chemistry Oxygen - metabolism Pain Rats Rats, Sprague-Dawley Temperature TRPV Cation Channels - metabolism Unsaturated fatty acids
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