Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults

Plasma homocysteine (Hcy) level is associated with cardiovascular disease and may play an etiologic role in vascular damage, a precursor for atherosclerosis. We performed a genome-wide association study for Hcy in 1786 unrelated Filipino women from the Cebu Longitudinal Health and Nutrition Survey (...

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Veröffentlicht in:	Human molecular genetics 2010-05, Vol.19 (10), p.2050-2058
Hauptverfasser:	Lange, Leslie A., Croteau-Chonka, Damien C., Marvelle, Amanda F., Qin, Li, Gaulton, Kyle J., Kuzawa, Christopher W., McDade, Thomas W., Wang, Yunfei, Li, Yun, Levy, Shawn, Borja, Judith B., Lange, Ethan M., Adair, Linda S., Mohlke, Karen L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Association Studies Biological and medical sciences Carbamoyl-Phosphate Synthase (Ammonia) - genetics Cardiovascular Diseases - genetics Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Health Surveys Homocysteine - blood Humans Methylenetetrahydrofolate Reductase (NADPH2) - genetics Molecular and cellular biology Mothers Nutrition Surveys Philippines Polymorphism, Single Nucleotide - genetics Quantitative Trait Loci - genetics Reproducibility of Results Young Adult
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