Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution

Reduced-representation bisulfite sequencing, optimized for DNA amounts as low as 30 nanograms and robust enough to process DNA extracted from formalin-fixed, paraffin-embedded tissue, allows genome-scale mapping of DNA methylation in many samples. Bisulfite sequencing measures absolute levels of DNA...

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Veröffentlicht in:	Nature methods 2010-02, Vol.7 (2), p.133-136
Hauptverfasser:	Gu, Hongcang, Bock, Christoph, Mikkelsen, Tarjei S, Jäger, Natalie, Smith, Zachary D, Tomazou, Eleni, Gnirke, Andreas, Lander, Eric S, Meissner, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1513/1382 631/1647/514 631/337/176/1988 Base Sequence Bioinformatics Biological Microscopy Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology brief-communication Chromosome Mapping - methods Colonic Neoplasms - diagnosis Colonic Neoplasms - genetics Deoxyribonucleic acid DNA DNA Methylation - genetics DNA sequencing DNA, Neoplasm - genetics Genetic Testing - methods Genomics Humans Life Sciences Methylation Molecular Sequence Data Nucleotide sequencing Nucleotides - genetics Physiological aspects Proteomics Reproducibility of Results Sensitivity and Specificity Statistical methods
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