Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that positively regulates the basal and inducible expression of a large battery of cytoprotective genes. These gene products include proteins that catalyze reduction reactions (NAD(P)H:quinone oxidoreductase 1, Nqo1), conju...

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Veröffentlicht in:	Toxicology and applied pharmacology 2010-04, Vol.244 (1), p.57-65
Hauptverfasser:	Klaassen, Curtis D., Reisman, Scott A.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ANIMALS Antioxidants - metabolism AROMATICS BENZOQUINONES BODY Chemical and Drug Induced Liver Injury - genetics Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - prevention & control CHEMICAL REACTIONS CLEARANCE COENZYMES Cytoprotection DIGESTIVE SYSTEM DRUGS ENZYMES EXCRETION Gene Expression Regulation GENES GLANDS GLUTATHIONE Humans Inactivation, Metabolic - genetics KINETICS LIVER Liver - drug effects Liver - metabolism MAMMALS METABOLISM MICE Multidrug Resistance-Associated Proteins - metabolism NAD NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 NUCLEOTIDES ORGANIC COMPOUNDS ORGANIC OXYGEN COMPOUNDS ORGANS OXIDATION Oxidative Stress PATHOLOGY PEPTIDES POLYPEPTIDES PROTEINS QUINONES RADIOPROTECTIVE SUBSTANCES RESPONSE MODIFYING FACTORS RODENTS Signal Transduction - drug effects STRESSES TOXICITY Toxicodynamics Toxicokinetics TRANSCRIPTION FACTORS TRANSFERASES VERTEBRATES XENOBIOTICS
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