Estrogen is necessary for 5α-pregnan-3α-ol-20-one (3α,5α-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats
The progesterone metabolite, 5α-pregnan-3α-ol-20-one (3α,5α-THP, allopregnanolone), acts in the ventral tegmental area (VTA) to facilitate exploratory, anti-anxiety, and socio-sexual behavior among ovariectomized (OVX), estrogen (E 2)-primed rats and gonadally-intact rats with high (proestrus) or lo...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2008-12, Vol.91 (2), p.261-270 |
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| creator | Frye, C.A. Paris, J.J. Rhodes, M.E. |
| description | The progesterone metabolite, 5α-pregnan-3α-ol-20-one (3α,5α-THP, allopregnanolone), acts in the ventral tegmental area (VTA) to facilitate exploratory, anti-anxiety, and socio-sexual behavior among ovariectomized (OVX), estrogen (E
2)-primed rats and gonadally-intact rats with high (proestrus) or low (diestrus) endogenous E
2 levels. The extent to which E
2 is required for these effects of 3α,5α-THP is not known. OVX rats were primed with systemic 17β-estradiol (10 µg) or oil vehicle and were infused 44 h later with 3α,5α-THP (100 ng) or β-cyclodextrin vehicle to the VTA, substantia nigra (SN), or central grey (CG). Rats were assessed in a battery of exploratory (open field), anxiety (elevated plus maze), social (partner preference, social interaction), and sexual (paced mating) tasks. E
2-priming was necessary for 3α,5α-THP infusions to facilitate social interaction and mating and midbrain 3α,5α-THP levels were higher among E
2-compared to vehicle-primed rats. Irrespective of E
2-priming, rats infused with 3α,5α-THP to the VTA, but not SN or CG, demonstrated increased exploration in an open field, anti-anxiety behavior on an elevated plus maze, and preference for a male. Thus, actions of 3α,5α-THP in the VTA to enhance social and sexual behaviors were reliant on E
2 but increases in exploratory and anti-anxiety behavior were not. |
| doi_str_mv | 10.1016/j.pbb.2008.08.018 |
| format | Article |
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2)-primed rats and gonadally-intact rats with high (proestrus) or low (diestrus) endogenous E
2 levels. The extent to which E
2 is required for these effects of 3α,5α-THP is not known. OVX rats were primed with systemic 17β-estradiol (10 µg) or oil vehicle and were infused 44 h later with 3α,5α-THP (100 ng) or β-cyclodextrin vehicle to the VTA, substantia nigra (SN), or central grey (CG). Rats were assessed in a battery of exploratory (open field), anxiety (elevated plus maze), social (partner preference, social interaction), and sexual (paced mating) tasks. E
2-priming was necessary for 3α,5α-THP infusions to facilitate social interaction and mating and midbrain 3α,5α-THP levels were higher among E
2-compared to vehicle-primed rats. Irrespective of E
2-priming, rats infused with 3α,5α-THP to the VTA, but not SN or CG, demonstrated increased exploration in an open field, anti-anxiety behavior on an elevated plus maze, and preference for a male. Thus, actions of 3α,5α-THP in the VTA to enhance social and sexual behaviors were reliant on E
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2)-primed rats and gonadally-intact rats with high (proestrus) or low (diestrus) endogenous E
2 levels. The extent to which E
2 is required for these effects of 3α,5α-THP is not known. OVX rats were primed with systemic 17β-estradiol (10 µg) or oil vehicle and were infused 44 h later with 3α,5α-THP (100 ng) or β-cyclodextrin vehicle to the VTA, substantia nigra (SN), or central grey (CG). Rats were assessed in a battery of exploratory (open field), anxiety (elevated plus maze), social (partner preference, social interaction), and sexual (paced mating) tasks. E
2-priming was necessary for 3α,5α-THP infusions to facilitate social interaction and mating and midbrain 3α,5α-THP levels were higher among E
2-compared to vehicle-primed rats. Irrespective of E
2-priming, rats infused with 3α,5α-THP to the VTA, but not SN or CG, demonstrated increased exploration in an open field, anti-anxiety behavior on an elevated plus maze, and preference for a male. Thus, actions of 3α,5α-THP in the VTA to enhance social and sexual behaviors were reliant on E
2 but increases in exploratory and anti-anxiety behavior were not.</description><subject>Allopregnanolone</subject><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Diseases of the spine</subject><subject>GABA</subject><subject>Lordosis</subject><subject>Medical sciences</subject><subject>Non-genomic</subject><subject>Progesterone</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9UcGKFDEQDaK44-oHeMtFUNgek-5OJyIIsqyusKCH9Rwq6cpMhp5kSDLN6l_5I_pLppllwYtQkKp69V5Vqgh5ydmaMz683a0PxqxbxtR6Ma4ekRVXsmsEl_IxWTH2jjcdE_KMPMt5xxjr20E-JWe1SA1CqBX5c5VLihsM1Gca0GLOkH5QFxMVv381h4SbAKHpqh-npmVNDEhf1_BigW-vv72hPrhj9jHQEmnZIp0xlAQTLbjZV7d6kBAW1IH1ky9QkOZo_YKEkWa8O8J0Qc2x1Al8lUgU7w5TTFBinSXUWcA5tMXPSA1uYfY1FR2NMyRf83Hvf-JIa31-Tp44mDK-uH_PyfdPV7eX183N189fLj_eNLZvRWkMyH7sLW-VMnLoOyaRC4lolOocc1ZC72QnByZd74TqBEhjhVGc9UIKNN05-XDSPRzNHkd7-rM-JL-v-9MRvP4XCX6rN3HWrapynFUBfhKwKeac0D1wOdPLdfVO1-vq5bp6Ma4q59V9U8gWJpcgWJ8fiC1TQ6fEov3-VId1A7PHpLP1GCyOPtV16TH6_3T5C7lfwCc</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Frye, C.A.</creator><creator>Paris, J.J.</creator><creator>Rhodes, M.E.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20081201</creationdate><title>Estrogen is necessary for 5α-pregnan-3α-ol-20-one (3α,5α-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats</title><author>Frye, C.A. ; Paris, J.J. ; Rhodes, M.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-ba74d4c1288b764307e157eeb883f0fc7a4f737607f4f5835a7bc5b8104575eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Allopregnanolone</topic><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Diseases of the spine</topic><topic>GABA</topic><topic>Lordosis</topic><topic>Medical sciences</topic><topic>Non-genomic</topic><topic>Progesterone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frye, C.A.</creatorcontrib><creatorcontrib>Paris, J.J.</creatorcontrib><creatorcontrib>Rhodes, M.E.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frye, C.A.</au><au>Paris, J.J.</au><au>Rhodes, M.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estrogen is necessary for 5α-pregnan-3α-ol-20-one (3α,5α-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><date>2008-12-01</date><risdate>2008</risdate><volume>91</volume><issue>2</issue><spage>261</spage><epage>270</epage><pages>261-270</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>The progesterone metabolite, 5α-pregnan-3α-ol-20-one (3α,5α-THP, allopregnanolone), acts in the ventral tegmental area (VTA) to facilitate exploratory, anti-anxiety, and socio-sexual behavior among ovariectomized (OVX), estrogen (E
2)-primed rats and gonadally-intact rats with high (proestrus) or low (diestrus) endogenous E
2 levels. The extent to which E
2 is required for these effects of 3α,5α-THP is not known. OVX rats were primed with systemic 17β-estradiol (10 µg) or oil vehicle and were infused 44 h later with 3α,5α-THP (100 ng) or β-cyclodextrin vehicle to the VTA, substantia nigra (SN), or central grey (CG). Rats were assessed in a battery of exploratory (open field), anxiety (elevated plus maze), social (partner preference, social interaction), and sexual (paced mating) tasks. E
2-priming was necessary for 3α,5α-THP infusions to facilitate social interaction and mating and midbrain 3α,5α-THP levels were higher among E
2-compared to vehicle-primed rats. Irrespective of E
2-priming, rats infused with 3α,5α-THP to the VTA, but not SN or CG, demonstrated increased exploration in an open field, anti-anxiety behavior on an elevated plus maze, and preference for a male. Thus, actions of 3α,5α-THP in the VTA to enhance social and sexual behaviors were reliant on E
2 but increases in exploratory and anti-anxiety behavior were not.</abstract><cop>Kidlington</cop><pub>Elsevier Inc</pub><pmid>18786558</pmid><doi>10.1016/j.pbb.2008.08.018</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Allopregnanolone Biological and medical sciences Diseases of the osteoarticular system Diseases of the spine GABA Lordosis Medical sciences Non-genomic Progesterone |
| title | Estrogen is necessary for 5α-pregnan-3α-ol-20-one (3α,5α-THP) infusion to the ventral tegmental area to facilitate social and sexual, but neither exploratory nor affective behavior of ovariectomized rats |
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