An Elastic, Biodegradable Cardiac Patch Induces Contractile Smooth Muscle and Improves Cardiac Remodeling and Function in Subacute Myocardial Infarction
An Elastic, Biodegradable Cardiac Patch Induces Contractile Smooth Muscle and Improves Cardiac Remodeling and Function in Subacute Myocardial Infarction Kazuro L. Fujimoto, Kimimasa Tobita, W. David Merryman, Jianjun Guan, Nobuo Momoi, Donna B. Stolz, Michael S. Sacks, Bradley B. Keller, William R....
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| Veröffentlicht in: | Journal of the American College of Cardiology 2007-06, Vol.49 (23), p.2292-2300 |
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| creator | Fujimoto, Kazuro L., MD Tobita, Kimimasa, MD Merryman, W. David, PhD Guan, Jianjun, PhD Momoi, Nobuo, MD, PhD Stolz, Donna B., PhD Sacks, Michael S., PhD Keller, Bradley B., MD Wagner, William R., PhD |
| description | An Elastic, Biodegradable Cardiac Patch Induces Contractile Smooth Muscle and Improves Cardiac Remodeling and Function in Subacute Myocardial Infarction Kazuro L. Fujimoto, Kimimasa Tobita, W. David Merryman, Jianjun Guan, Nobuo Momoi, Donna B. Stolz, Michael S. Sacks, Bradley B. Keller, William R. Wagner To prevent chronic adverse cardiac remodeling and subsequent dysfunction after myocardial infarction, we implanted an elastic, biodegradable material, polyester urethane urea (PEUU), as a cardiac patch onto subacute infarcts in a rat model. Eight weeks after implantation, echocardiography revealed that cardiac dilatation was prevented and contractile function improved in the PEUU patch group. Histology revealed contractile smooth muscle bundles in the PEUU implanted site and increased wall thickness, compared to the infarction control. The myocardial compliance of the PEUU group was distributed between normal myocardium and the infarction control. These findings suggest a new therapeutic option against post-infarct cardiac failure. |
| doi_str_mv | 10.1016/j.jacc.2007.02.050 |
| format | Article |
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David, PhD ; Guan, Jianjun, PhD ; Momoi, Nobuo, MD, PhD ; Stolz, Donna B., PhD ; Sacks, Michael S., PhD ; Keller, Bradley B., MD ; Wagner, William R., PhD</creator><creatorcontrib>Fujimoto, Kazuro L., MD ; Tobita, Kimimasa, MD ; Merryman, W. David, PhD ; Guan, Jianjun, PhD ; Momoi, Nobuo, MD, PhD ; Stolz, Donna B., PhD ; Sacks, Michael S., PhD ; Keller, Bradley B., MD ; Wagner, William R., PhD</creatorcontrib><description>An Elastic, Biodegradable Cardiac Patch Induces Contractile Smooth Muscle and Improves Cardiac Remodeling and Function in Subacute Myocardial Infarction Kazuro L. Fujimoto, Kimimasa Tobita, W. David Merryman, Jianjun Guan, Nobuo Momoi, Donna B. Stolz, Michael S. Sacks, Bradley B. Keller, William R. Wagner To prevent chronic adverse cardiac remodeling and subsequent dysfunction after myocardial infarction, we implanted an elastic, biodegradable material, polyester urethane urea (PEUU), as a cardiac patch onto subacute infarcts in a rat model. Eight weeks after implantation, echocardiography revealed that cardiac dilatation was prevented and contractile function improved in the PEUU patch group. Histology revealed contractile smooth muscle bundles in the PEUU implanted site and increased wall thickness, compared to the infarction control. The myocardial compliance of the PEUU group was distributed between normal myocardium and the infarction control. These findings suggest a new therapeutic option against post-infarct cardiac failure.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2007.02.050</identifier><identifier>PMID: 17560295</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biocompatible Materials - administration & dosage ; Biodegradation ; Biological and medical sciences ; Capillaries - drug effects ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Compliance - drug effects ; Female ; Fibroblast Growth Factor 2 - drug effects ; Heart - drug effects ; Heart attacks ; Hypotheses ; Internal Medicine ; Medical sciences ; Muscular system ; Myocardial Contraction - drug effects ; Myocardial Infarction - pathology ; Myocardial Infarction - physiopathology ; Myocardial Infarction - therapy ; Myocardium - pathology ; Ostomy ; Polyesters ; Polyurethanes - administration & dosage ; Rats ; Rats, Inbred Lew ; Rodents ; Smooth muscle ; Studies ; Tissue engineering ; Vascular Endothelial Growth Factor A - drug effects ; Veins & arteries ; Ventricular Remodeling - drug effects</subject><ispartof>Journal of the American College of Cardiology, 2007-06, Vol.49 (23), p.2292-2300</ispartof><rights>American College of Cardiology Foundation</rights><rights>2007 American College of Cardiology Foundation</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jun 12, 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c602t-2ca0aaa89e9cb78038d46d71f23f518ba0d6c10b90b2adfedb1e02b33e1aac8b3</citedby><cites>FETCH-LOGICAL-c602t-2ca0aaa89e9cb78038d46d71f23f518ba0d6c10b90b2adfedb1e02b33e1aac8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jacc.2007.02.050$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,3551,27925,27926,45996</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18831252$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17560295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujimoto, Kazuro L., MD</creatorcontrib><creatorcontrib>Tobita, Kimimasa, MD</creatorcontrib><creatorcontrib>Merryman, W. David, PhD</creatorcontrib><creatorcontrib>Guan, Jianjun, PhD</creatorcontrib><creatorcontrib>Momoi, Nobuo, MD, PhD</creatorcontrib><creatorcontrib>Stolz, Donna B., PhD</creatorcontrib><creatorcontrib>Sacks, Michael S., PhD</creatorcontrib><creatorcontrib>Keller, Bradley B., MD</creatorcontrib><creatorcontrib>Wagner, William R., PhD</creatorcontrib><title>An Elastic, Biodegradable Cardiac Patch Induces Contractile Smooth Muscle and Improves Cardiac Remodeling and Function in Subacute Myocardial Infarction</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>An Elastic, Biodegradable Cardiac Patch Induces Contractile Smooth Muscle and Improves Cardiac Remodeling and Function in Subacute Myocardial Infarction Kazuro L. Fujimoto, Kimimasa Tobita, W. David Merryman, Jianjun Guan, Nobuo Momoi, Donna B. Stolz, Michael S. Sacks, Bradley B. Keller, William R. Wagner To prevent chronic adverse cardiac remodeling and subsequent dysfunction after myocardial infarction, we implanted an elastic, biodegradable material, polyester urethane urea (PEUU), as a cardiac patch onto subacute infarcts in a rat model. Eight weeks after implantation, echocardiography revealed that cardiac dilatation was prevented and contractile function improved in the PEUU patch group. Histology revealed contractile smooth muscle bundles in the PEUU implanted site and increased wall thickness, compared to the infarction control. The myocardial compliance of the PEUU group was distributed between normal myocardium and the infarction control. These findings suggest a new therapeutic option against post-infarct cardiac failure.</description><subject>Animals</subject><subject>Biocompatible Materials - administration & dosage</subject><subject>Biodegradation</subject><subject>Biological and medical sciences</subject><subject>Capillaries - drug effects</subject><subject>Cardiology</subject><subject>Cardiology. 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David, PhD</au><au>Guan, Jianjun, PhD</au><au>Momoi, Nobuo, MD, PhD</au><au>Stolz, Donna B., PhD</au><au>Sacks, Michael S., PhD</au><au>Keller, Bradley B., MD</au><au>Wagner, William R., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Elastic, Biodegradable Cardiac Patch Induces Contractile Smooth Muscle and Improves Cardiac Remodeling and Function in Subacute Myocardial Infarction</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2007-06-12</date><risdate>2007</risdate><volume>49</volume><issue>23</issue><spage>2292</spage><epage>2300</epage><pages>2292-2300</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>An Elastic, Biodegradable Cardiac Patch Induces Contractile Smooth Muscle and Improves Cardiac Remodeling and Function in Subacute Myocardial Infarction Kazuro L. Fujimoto, Kimimasa Tobita, W. David Merryman, Jianjun Guan, Nobuo Momoi, Donna B. Stolz, Michael S. Sacks, Bradley B. Keller, William R. Wagner To prevent chronic adverse cardiac remodeling and subsequent dysfunction after myocardial infarction, we implanted an elastic, biodegradable material, polyester urethane urea (PEUU), as a cardiac patch onto subacute infarcts in a rat model. Eight weeks after implantation, echocardiography revealed that cardiac dilatation was prevented and contractile function improved in the PEUU patch group. Histology revealed contractile smooth muscle bundles in the PEUU implanted site and increased wall thickness, compared to the infarction control. The myocardial compliance of the PEUU group was distributed between normal myocardium and the infarction control. These findings suggest a new therapeutic option against post-infarct cardiac failure.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17560295</pmid><doi>10.1016/j.jacc.2007.02.050</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biocompatible Materials - administration & dosage Biodegradation Biological and medical sciences Capillaries - drug effects Cardiology Cardiology. Vascular system Cardiovascular Compliance - drug effects Female Fibroblast Growth Factor 2 - drug effects Heart - drug effects Heart attacks Hypotheses Internal Medicine Medical sciences Muscular system Myocardial Contraction - drug effects Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - therapy Myocardium - pathology Ostomy Polyesters Polyurethanes - administration & dosage Rats Rats, Inbred Lew Rodents Smooth muscle Studies Tissue engineering Vascular Endothelial Growth Factor A - drug effects Veins & arteries Ventricular Remodeling - drug effects |
| title | An Elastic, Biodegradable Cardiac Patch Induces Contractile Smooth Muscle and Improves Cardiac Remodeling and Function in Subacute Myocardial Infarction |
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