Ligand Binding and Subtype Selectivity of the Human A₂A Adenosine Receptor: IDENTIFICATION AND CHARACTERIZATION OF ESSENTIAL AMINO ACID RESIDUES

The crystal structure of the human A₂A adenosine receptor bound to the A₂A receptor-specific antagonist, ZM241385, was recently determined at 2.6-Å resolution. Surprisingly, the antagonist binds in an extended conformation, perpendicular to the plane of the membrane, and indicates a number of intera...

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Veröffentlicht in:	The Journal of biological chemistry 2010-04, Vol.285 (17), p.13032-13044
Hauptverfasser:	Jaakola, Veli-Pekka, Lane, J. Robert, Lin, Judy Y, Katritch, Vsevolod, IJzerman, Adriaan P, Stevens, Raymond C
Format:	Artikel
Sprache:	eng
Schlagworte:	Membrane Biology
Online-Zugang:	Volltext
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