Omega-3 fatty acids in dry eye and corneal nerve regeneration after refractive surgery
Abstract Dry eye (DE) is a multifactorial condition that affects the surface of the eye and induces an inflammatory response. Corneal nerves play an important role in the maintenance of a healthy ocular surface. Here we review corneal structure, nerve architecture, DE conditions, and nerve regenerat...
Gespeichert in:
| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2010-04, Vol.82 (4), p.319-325 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 325 |
|---|---|
| container_issue | 4 |
| container_start_page | 319 |
| container_title | Prostaglandins, leukotrienes and essential fatty acids |
| container_volume | 82 |
| creator | He, Jiucheng Bazan, Haydee E.P |
| description | Abstract Dry eye (DE) is a multifactorial condition that affects the surface of the eye and induces an inflammatory response. Corneal nerves play an important role in the maintenance of a healthy ocular surface. Here we review corneal structure, nerve architecture, DE conditions, and nerve regeneration following corneal surgery and discuss how n-3 fatty acids affect the health of the cornea. Animal studies show that resolvins, compounds derived from eicosapentaenoic acid (EPA), increase tear volume and decrease inflammation induced by DE. After corneal surgery in rabbits, treatment with nerve growth factor (NGF) or pigment epithelial derived factor (PEDF) in conjunction with docosahexaenoic acid (DHA) increase nerve density and corneal epithelial cell proliferation. Increased synthesis of the novel docosanoid, neuroprotectin D1 (NPD1), was found in corneas after the animals were treated with PEDF and DHA. Topical application of these lipids derived from n-3 fatty acids could be useful in treating DE and prevent clinical complications such as cornea erosion and ulcerations. |
| doi_str_mv | 10.1016/j.plefa.2010.02.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2856794</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0952327810000487</els_id><sourcerecordid>733896142</sourcerecordid><originalsourceid>FETCH-LOGICAL-c575t-df266eed1c7e840d96962c7c0334e0c2c25b9e523c34cfbda8a687d2295917513</originalsourceid><addsrcrecordid>eNqFkk1vEzEQhi0EoqHwC5CQL4jTBn-udw9UqiooSJV64ONqOePZ4LDxBns30v57HJKWj0vlg63xM-PxvC8hLzlbcsbrt5vlrsfOLQUrESaWjKlHZMG1FJVohHxMFqzVopLCNGfkWc4bxpjgXD0lZ4KV1TC1IN9ut7h2laSdG8eZOgg-0xCpTzPFGamLnsKQIrqeRkx7pAnXWE5uDEOkrhsxlVCXHIyh3OYprTHNz8mTzvUZX5z2c_L1w_svVx-rm9vrT1eXNxVoo8fKd6KuET0Hg41ivq3bWoABJqVCBgKEXrWohQSpoFt517i6MV6IVrfcaC7PycWx7m5abdEDxjG53u5S2Lo028EF--9NDN_tethb0ejatKoUeHMqkIafE-bRbkMG7HsXcZiyNUq30nAuHyalbNqaK1FIeSQhDTmX4dz3w5k9SGc39rd09iCdZcIW6UrWq7-_cp9zp1UBXp8Al8H1ZeQRQv7DCaONYqZw744clsHvAyabIWAE9CEhjNYP4YFGLv7Lhz7EUJ78URyRN8OUYtHUcptLgv18cNnBZLz4i6nGyF8Vfc1o</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733896142</pqid></control><display><type>article</type><title>Omega-3 fatty acids in dry eye and corneal nerve regeneration after refractive surgery</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>He, Jiucheng ; Bazan, Haydee E.P</creator><creatorcontrib>He, Jiucheng ; Bazan, Haydee E.P</creatorcontrib><description>Abstract Dry eye (DE) is a multifactorial condition that affects the surface of the eye and induces an inflammatory response. Corneal nerves play an important role in the maintenance of a healthy ocular surface. Here we review corneal structure, nerve architecture, DE conditions, and nerve regeneration following corneal surgery and discuss how n-3 fatty acids affect the health of the cornea. Animal studies show that resolvins, compounds derived from eicosapentaenoic acid (EPA), increase tear volume and decrease inflammation induced by DE. After corneal surgery in rabbits, treatment with nerve growth factor (NGF) or pigment epithelial derived factor (PEDF) in conjunction with docosahexaenoic acid (DHA) increase nerve density and corneal epithelial cell proliferation. Increased synthesis of the novel docosanoid, neuroprotectin D1 (NPD1), was found in corneas after the animals were treated with PEDF and DHA. Topical application of these lipids derived from n-3 fatty acids could be useful in treating DE and prevent clinical complications such as cornea erosion and ulcerations.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1016/j.plefa.2010.02.004</identifier><identifier>PMID: 20202804</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Advanced Basic Science ; Animals ; Biological and medical sciences ; Cell Proliferation - drug effects ; Cornea - metabolism ; Cornea - surgery ; Corneal Injuries ; Docosahexaenoic Acids - metabolism ; Dry Eye Syndromes - drug therapy ; Dry Eye Syndromes - pathology ; Endocrinology & Metabolism ; Epithelium, Corneal - cytology ; Epithelium, Corneal - drug effects ; Epithelium, Corneal - metabolism ; Fatty Acids, Omega-3 - therapeutic use ; Fundamental and applied biological sciences. Psychology ; Humans ; Nerve Regeneration - drug effects ; Refractive Surgical Procedures - methods ; Vertebrates: endocrinology</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 2010-04, Vol.82 (4), p.319-325</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Ltd. All rights reserved.</rights><rights>2010 Elsevier Ltd. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-df266eed1c7e840d96962c7c0334e0c2c25b9e523c34cfbda8a687d2295917513</citedby><cites>FETCH-LOGICAL-c575t-df266eed1c7e840d96962c7c0334e0c2c25b9e523c34cfbda8a687d2295917513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.plefa.2010.02.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,309,310,314,780,784,789,790,885,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22757407$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20202804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>He, Jiucheng</creatorcontrib><creatorcontrib>Bazan, Haydee E.P</creatorcontrib><title>Omega-3 fatty acids in dry eye and corneal nerve regeneration after refractive surgery</title><title>Prostaglandins, leukotrienes and essential fatty acids</title><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><description>Abstract Dry eye (DE) is a multifactorial condition that affects the surface of the eye and induces an inflammatory response. Corneal nerves play an important role in the maintenance of a healthy ocular surface. Here we review corneal structure, nerve architecture, DE conditions, and nerve regeneration following corneal surgery and discuss how n-3 fatty acids affect the health of the cornea. Animal studies show that resolvins, compounds derived from eicosapentaenoic acid (EPA), increase tear volume and decrease inflammation induced by DE. After corneal surgery in rabbits, treatment with nerve growth factor (NGF) or pigment epithelial derived factor (PEDF) in conjunction with docosahexaenoic acid (DHA) increase nerve density and corneal epithelial cell proliferation. Increased synthesis of the novel docosanoid, neuroprotectin D1 (NPD1), was found in corneas after the animals were treated with PEDF and DHA. Topical application of these lipids derived from n-3 fatty acids could be useful in treating DE and prevent clinical complications such as cornea erosion and ulcerations.</description><subject>Advanced Basic Science</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Proliferation - drug effects</subject><subject>Cornea - metabolism</subject><subject>Cornea - surgery</subject><subject>Corneal Injuries</subject><subject>Docosahexaenoic Acids - metabolism</subject><subject>Dry Eye Syndromes - drug therapy</subject><subject>Dry Eye Syndromes - pathology</subject><subject>Endocrinology & Metabolism</subject><subject>Epithelium, Corneal - cytology</subject><subject>Epithelium, Corneal - drug effects</subject><subject>Epithelium, Corneal - metabolism</subject><subject>Fatty Acids, Omega-3 - therapeutic use</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Nerve Regeneration - drug effects</subject><subject>Refractive Surgical Procedures - methods</subject><subject>Vertebrates: endocrinology</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1vEzEQhi0EoqHwC5CQL4jTBn-udw9UqiooSJV64ONqOePZ4LDxBns30v57HJKWj0vlg63xM-PxvC8hLzlbcsbrt5vlrsfOLQUrESaWjKlHZMG1FJVohHxMFqzVopLCNGfkWc4bxpjgXD0lZ4KV1TC1IN9ut7h2laSdG8eZOgg-0xCpTzPFGamLnsKQIrqeRkx7pAnXWE5uDEOkrhsxlVCXHIyh3OYprTHNz8mTzvUZX5z2c_L1w_svVx-rm9vrT1eXNxVoo8fKd6KuET0Hg41ivq3bWoABJqVCBgKEXrWohQSpoFt517i6MV6IVrfcaC7PycWx7m5abdEDxjG53u5S2Lo028EF--9NDN_tethb0ejatKoUeHMqkIafE-bRbkMG7HsXcZiyNUq30nAuHyalbNqaK1FIeSQhDTmX4dz3w5k9SGc39rd09iCdZcIW6UrWq7-_cp9zp1UBXp8Al8H1ZeQRQv7DCaONYqZw744clsHvAyabIWAE9CEhjNYP4YFGLv7Lhz7EUJ78URyRN8OUYtHUcptLgv18cNnBZLz4i6nGyF8Vfc1o</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>He, Jiucheng</creator><creator>Bazan, Haydee E.P</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20100401</creationdate><title>Omega-3 fatty acids in dry eye and corneal nerve regeneration after refractive surgery</title><author>He, Jiucheng ; Bazan, Haydee E.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c575t-df266eed1c7e840d96962c7c0334e0c2c25b9e523c34cfbda8a687d2295917513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Advanced Basic Science</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Proliferation - drug effects</topic><topic>Cornea - metabolism</topic><topic>Cornea - surgery</topic><topic>Corneal Injuries</topic><topic>Docosahexaenoic Acids - metabolism</topic><topic>Dry Eye Syndromes - drug therapy</topic><topic>Dry Eye Syndromes - pathology</topic><topic>Endocrinology & Metabolism</topic><topic>Epithelium, Corneal - cytology</topic><topic>Epithelium, Corneal - drug effects</topic><topic>Epithelium, Corneal - metabolism</topic><topic>Fatty Acids, Omega-3 - therapeutic use</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Nerve Regeneration - drug effects</topic><topic>Refractive Surgical Procedures - methods</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>He, Jiucheng</creatorcontrib><creatorcontrib>Bazan, Haydee E.P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>He, Jiucheng</au><au>Bazan, Haydee E.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Omega-3 fatty acids in dry eye and corneal nerve regeneration after refractive surgery</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>82</volume><issue>4</issue><spage>319</spage><epage>325</epage><pages>319-325</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>Abstract Dry eye (DE) is a multifactorial condition that affects the surface of the eye and induces an inflammatory response. Corneal nerves play an important role in the maintenance of a healthy ocular surface. Here we review corneal structure, nerve architecture, DE conditions, and nerve regeneration following corneal surgery and discuss how n-3 fatty acids affect the health of the cornea. Animal studies show that resolvins, compounds derived from eicosapentaenoic acid (EPA), increase tear volume and decrease inflammation induced by DE. After corneal surgery in rabbits, treatment with nerve growth factor (NGF) or pigment epithelial derived factor (PEDF) in conjunction with docosahexaenoic acid (DHA) increase nerve density and corneal epithelial cell proliferation. Increased synthesis of the novel docosanoid, neuroprotectin D1 (NPD1), was found in corneas after the animals were treated with PEDF and DHA. Topical application of these lipids derived from n-3 fatty acids could be useful in treating DE and prevent clinical complications such as cornea erosion and ulcerations.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20202804</pmid><doi>10.1016/j.plefa.2010.02.004</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0952-3278 |
| ispartof | Prostaglandins, leukotrienes and essential fatty acids, 2010-04, Vol.82 (4), p.319-325 |
| issn | 0952-3278 1532-2823 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2856794 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Advanced Basic Science Animals Biological and medical sciences Cell Proliferation - drug effects Cornea - metabolism Cornea - surgery Corneal Injuries Docosahexaenoic Acids - metabolism Dry Eye Syndromes - drug therapy Dry Eye Syndromes - pathology Endocrinology & Metabolism Epithelium, Corneal - cytology Epithelium, Corneal - drug effects Epithelium, Corneal - metabolism Fatty Acids, Omega-3 - therapeutic use Fundamental and applied biological sciences. Psychology Humans Nerve Regeneration - drug effects Refractive Surgical Procedures - methods Vertebrates: endocrinology |
| title | Omega-3 fatty acids in dry eye and corneal nerve regeneration after refractive surgery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T22%3A41%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Omega-3%20fatty%20acids%20in%20dry%20eye%20and%20corneal%20nerve%20regeneration%20after%20refractive%20surgery&rft.jtitle=Prostaglandins,%20leukotrienes%20and%20essential%20fatty%20acids&rft.au=He,%20Jiucheng&rft.date=2010-04-01&rft.volume=82&rft.issue=4&rft.spage=319&rft.epage=325&rft.pages=319-325&rft.issn=0952-3278&rft.eissn=1532-2823&rft_id=info:doi/10.1016/j.plefa.2010.02.004&rft_dat=%3Cproquest_pubme%3E733896142%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733896142&rft_id=info:pmid/20202804&rft_els_id=1_s2_0_S0952327810000487&rfr_iscdi=true |