The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: III. Radiation Risks
Romanenko, A. Ye., Finch, S. C., Hatch, M., Lubin, J. H., Bebeshko, V. G., Bazyka, D. A., Gudzenko, N., Dyagil, I. S., Reiss, R. F., Bouville, A., Chumak, V. V., Trotsiuk, N. K., Babkina, N. G., Belyayev, Yu., Masnyk, I., Ron, E., Howe, G.;thR. and Zablotska, L. B. The Ukrainian-American Study of Le...
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| creator | Romanenko, Anatoly Ye Finch, Stuart C. Hatch, Maureen Lubin, Jay H. Bebeshko, Volodymyr G. Bazyka, Dimitry A. Gudzenko, Nataliya Dyagil, Irina S. Reiss, Robert F. Bouville, Andre Chumak, Vadim V. Trotsiuk, Nataliya K. Babkina, Nataliya G. Belyayev, Yuri Masnyk, Ihor Ron, Elaine Howe, Geoffrey R. Zablotska, Lydia B. |
| description | Romanenko, A. Ye., Finch, S. C., Hatch, M., Lubin, J. H., Bebeshko, V. G., Bazyka, D. A., Gudzenko, N., Dyagil, I. S., Reiss, R. F., Bouville, A., Chumak, V. V., Trotsiuk, N. K., Babkina, N. G., Belyayev, Yu., Masnyk, I., Ron, E., Howe, G.;thR. and Zablotska, L. B. The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: III. Radiation Risks. Radiat. Res. 170, 711–720 (2008). Leukemia is one of the cancers most susceptible to induction by ionizing radiation, but the effects of lower doses delivered over time have not been quantified adequately. After the Chornobyl (Chernobyl) accident in Ukraine in April 1986, several hundred thousand workers who were involved in cleaning up the site and its surroundings received fractionated exposure, primarily from external γ radiation. To increase our understanding of the role of protracted low-dose radiation exposure in the etiology of leukemia, we conducted a nested case-control study of leukemia in a cohort of cleanup workers identified from the Chornobyl State Registry of Ukraine. The analysis is based on 71 cases of histologically confirmed leukemia diagnosed in 1986–2000 and 501 age- and residence-matched controls selected from the same cohort. Study subjects or their proxies were interviewed about their cleanup activities and other relevant factors. Individual bone marrow radiation doses were estimated by the RADRUE dose reconstruction method (mean dose = 76.4 mGy, SD = 213.4). We used conditional logistic regression to estimate leukemia risks. The excess relative risk (ERR) of total leukemia was 3.44 per Gy [95% confidence interval (CI) 0.47–9.78, P < 0.01]. The dose response was linear and did not differ significantly by calendar period of first work in the 30-km Chornobyl zone, duration or type of work. We found a similar dose–response relationship for chronic and non-chronic lymphocytic leukemia [ERR = 4.09 per Gy (95% CI < 0–14.41) and 2.73 per Gy (95% CI < 0–13.50), respectively]. To further clarify these issues, we are extending the case-control study to ascertain cases for another 6 years (2001–2006). |
| doi_str_mv | 10.1667/RR1404.1 |
| format | Article |
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S., Reiss, R. F., Bouville, A., Chumak, V. V., Trotsiuk, N. K., Babkina, N. G., Belyayev, Yu., Masnyk, I., Ron, E., Howe, G.;thR. and Zablotska, L. B. The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: III. Radiation Risks. Radiat. Res. 170, 711–720 (2008). Leukemia is one of the cancers most susceptible to induction by ionizing radiation, but the effects of lower doses delivered over time have not been quantified adequately. After the Chornobyl (Chernobyl) accident in Ukraine in April 1986, several hundred thousand workers who were involved in cleaning up the site and its surroundings received fractionated exposure, primarily from external γ radiation. To increase our understanding of the role of protracted low-dose radiation exposure in the etiology of leukemia, we conducted a nested case-control study of leukemia in a cohort of cleanup workers identified from the Chornobyl State Registry of Ukraine. The analysis is based on 71 cases of histologically confirmed leukemia diagnosed in 1986–2000 and 501 age- and residence-matched controls selected from the same cohort. Study subjects or their proxies were interviewed about their cleanup activities and other relevant factors. Individual bone marrow radiation doses were estimated by the RADRUE dose reconstruction method (mean dose = 76.4 mGy, SD = 213.4). We used conditional logistic regression to estimate leukemia risks. The excess relative risk (ERR) of total leukemia was 3.44 per Gy [95% confidence interval (CI) 0.47–9.78, P < 0.01]. The dose response was linear and did not differ significantly by calendar period of first work in the 30-km Chornobyl zone, duration or type of work. We found a similar dose–response relationship for chronic and non-chronic lymphocytic leukemia [ERR = 4.09 per Gy (95% CI < 0–14.41) and 2.73 per Gy (95% CI < 0–13.50), respectively]. To further clarify these issues, we are extending the case-control study to ascertain cases for another 6 years (2001–2006).</description><identifier>ISSN: 0033-7587</identifier><identifier>EISSN: 1938-5404</identifier><identifier>DOI: 10.1667/RR1404.1</identifier><identifier>PMID: 19138038</identifier><language>eng</language><publisher>United States: Radiation Research Society</publisher><subject>Adult ; Age Distribution ; Aged ; Case-Control Studies ; Chernobyl Nuclear Accident ; Chronic lymphocytic leukemia ; Cohort Studies ; Dose response relationship ; Dosimetry ; Environmental Restoration and Remediation ; Humans ; Ionizing radiation ; Leukemia ; Leukemia - epidemiology ; Leukemia - etiology ; Leukemia - pathology ; Logistic Models ; Male ; Membrane Proteins ; Middle Aged ; Neoplasms, Radiation-Induced - epidemiology ; Occupational Exposure ; P values ; Proxy reporting ; Proxy statements ; Radiation Dosage ; Radiation dose response relationship ; REGULAR ARTICLES ; Risk Assessment ; Time Factors ; Tumor Suppressor Proteins ; Ukraine - epidemiology ; United States</subject><ispartof>Radiation research, 2008-12, Vol.170 (6), p.711-720</ispartof><rights>The Radiation Research Society</rights><rights>Copyright 2008 The Radiation Research society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b520t-53472d553962627b69509e4a96eb9bdf5291effe06650a294d6b1bd26a8fbd133</citedby><cites>FETCH-LOGICAL-b520t-53472d553962627b69509e4a96eb9bdf5291effe06650a294d6b1bd26a8fbd133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bioone.org/doi/pdf/10.1667/RR1404.1$$EPDF$$P50$$Gbioone$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25167829$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,26957,27903,27904,52341,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19138038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romanenko, Anatoly Ye</creatorcontrib><creatorcontrib>Finch, Stuart C.</creatorcontrib><creatorcontrib>Hatch, Maureen</creatorcontrib><creatorcontrib>Lubin, Jay H.</creatorcontrib><creatorcontrib>Bebeshko, Volodymyr G.</creatorcontrib><creatorcontrib>Bazyka, Dimitry A.</creatorcontrib><creatorcontrib>Gudzenko, Nataliya</creatorcontrib><creatorcontrib>Dyagil, Irina S.</creatorcontrib><creatorcontrib>Reiss, Robert F.</creatorcontrib><creatorcontrib>Bouville, Andre</creatorcontrib><creatorcontrib>Chumak, Vadim V.</creatorcontrib><creatorcontrib>Trotsiuk, Nataliya K.</creatorcontrib><creatorcontrib>Babkina, Nataliya G.</creatorcontrib><creatorcontrib>Belyayev, Yuri</creatorcontrib><creatorcontrib>Masnyk, Ihor</creatorcontrib><creatorcontrib>Ron, Elaine</creatorcontrib><creatorcontrib>Howe, Geoffrey R.</creatorcontrib><creatorcontrib>Zablotska, Lydia B.</creatorcontrib><title>The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: III. Radiation Risks</title><title>Radiation research</title><addtitle>Radiat Res</addtitle><description>Romanenko, A. Ye., Finch, S. C., Hatch, M., Lubin, J. H., Bebeshko, V. G., Bazyka, D. A., Gudzenko, N., Dyagil, I. S., Reiss, R. F., Bouville, A., Chumak, V. V., Trotsiuk, N. K., Babkina, N. G., Belyayev, Yu., Masnyk, I., Ron, E., Howe, G.;thR. and Zablotska, L. B. The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: III. Radiation Risks. Radiat. Res. 170, 711–720 (2008). Leukemia is one of the cancers most susceptible to induction by ionizing radiation, but the effects of lower doses delivered over time have not been quantified adequately. After the Chornobyl (Chernobyl) accident in Ukraine in April 1986, several hundred thousand workers who were involved in cleaning up the site and its surroundings received fractionated exposure, primarily from external γ radiation. To increase our understanding of the role of protracted low-dose radiation exposure in the etiology of leukemia, we conducted a nested case-control study of leukemia in a cohort of cleanup workers identified from the Chornobyl State Registry of Ukraine. The analysis is based on 71 cases of histologically confirmed leukemia diagnosed in 1986–2000 and 501 age- and residence-matched controls selected from the same cohort. Study subjects or their proxies were interviewed about their cleanup activities and other relevant factors. Individual bone marrow radiation doses were estimated by the RADRUE dose reconstruction method (mean dose = 76.4 mGy, SD = 213.4). We used conditional logistic regression to estimate leukemia risks. The excess relative risk (ERR) of total leukemia was 3.44 per Gy [95% confidence interval (CI) 0.47–9.78, P < 0.01]. The dose response was linear and did not differ significantly by calendar period of first work in the 30-km Chornobyl zone, duration or type of work. We found a similar dose–response relationship for chronic and non-chronic lymphocytic leukemia [ERR = 4.09 per Gy (95% CI < 0–14.41) and 2.73 per Gy (95% CI < 0–13.50), respectively]. To further clarify these issues, we are extending the case-control study to ascertain cases for another 6 years (2001–2006).</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Chernobyl Nuclear Accident</subject><subject>Chronic lymphocytic leukemia</subject><subject>Cohort Studies</subject><subject>Dose response relationship</subject><subject>Dosimetry</subject><subject>Environmental Restoration and Remediation</subject><subject>Humans</subject><subject>Ionizing radiation</subject><subject>Leukemia</subject><subject>Leukemia - epidemiology</subject><subject>Leukemia - etiology</subject><subject>Leukemia - pathology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Membrane Proteins</subject><subject>Middle Aged</subject><subject>Neoplasms, Radiation-Induced - epidemiology</subject><subject>Occupational Exposure</subject><subject>P values</subject><subject>Proxy reporting</subject><subject>Proxy statements</subject><subject>Radiation Dosage</subject><subject>Radiation dose response relationship</subject><subject>REGULAR ARTICLES</subject><subject>Risk Assessment</subject><subject>Time Factors</subject><subject>Tumor Suppressor Proteins</subject><subject>Ukraine - epidemiology</subject><subject>United States</subject><issn>0033-7587</issn><issn>1938-5404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV9rFDEUxYModq2CX0DJk_gya_5MMhMfhLLaurAgjC0-hmRzp5vuTLImM8I--s2dZZfWPvTpcjg_zrlwEHpLyZxKWX1qGlqSck6foRlVvC7EpJ6jGSGcF5WoqzP0Kuc7Mmkq1Ut0RhXlNeH1DP293gC-2SbjgzehuOgh-bUJ-Ocwuj2OLV7BuIXeG2yCww10ZgCHv_ock4OUseljuMWLTUwh2n2HFx2YMO7wr5i2B79NsT_lw2e8XC7nuDHOm8HHgBuft_k1etGaLsOb0z1HN5ffrhffi9WPq-XiYlVYwchQCF5WzAnBlWSSVVYqQRSURkmwyrpWMEWhbYFIKYhhqnTSUuuYNHVrHeX8HH055u5G24NbQxiS6fQu-d6kvY7G68dO8Bt9G_9oVgspySHgwykgxd8j5EH3Pq-h60yAOGbNyNRKVTWBH4_gOsWcE7T3JZTow176uJemE_r-_6cewNNAE_DuCNzlIaZ7nwkqq5qph6esjzHA003_ACKKp3E</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Romanenko, Anatoly Ye</creator><creator>Finch, Stuart C.</creator><creator>Hatch, Maureen</creator><creator>Lubin, Jay H.</creator><creator>Bebeshko, Volodymyr G.</creator><creator>Bazyka, Dimitry A.</creator><creator>Gudzenko, Nataliya</creator><creator>Dyagil, Irina S.</creator><creator>Reiss, Robert F.</creator><creator>Bouville, Andre</creator><creator>Chumak, Vadim V.</creator><creator>Trotsiuk, Nataliya K.</creator><creator>Babkina, Nataliya G.</creator><creator>Belyayev, Yuri</creator><creator>Masnyk, Ihor</creator><creator>Ron, Elaine</creator><creator>Howe, Geoffrey R.</creator><creator>Zablotska, Lydia B.</creator><general>Radiation Research Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>200812</creationdate><title>The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: III. 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Radiation Risks</atitle><jtitle>Radiation research</jtitle><addtitle>Radiat Res</addtitle><date>2008-12</date><risdate>2008</risdate><volume>170</volume><issue>6</issue><spage>711</spage><epage>720</epage><pages>711-720</pages><issn>0033-7587</issn><eissn>1938-5404</eissn><abstract>Romanenko, A. Ye., Finch, S. C., Hatch, M., Lubin, J. H., Bebeshko, V. G., Bazyka, D. A., Gudzenko, N., Dyagil, I. S., Reiss, R. F., Bouville, A., Chumak, V. V., Trotsiuk, N. K., Babkina, N. G., Belyayev, Yu., Masnyk, I., Ron, E., Howe, G.;thR. and Zablotska, L. B. The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: III. Radiation Risks. Radiat. Res. 170, 711–720 (2008). Leukemia is one of the cancers most susceptible to induction by ionizing radiation, but the effects of lower doses delivered over time have not been quantified adequately. After the Chornobyl (Chernobyl) accident in Ukraine in April 1986, several hundred thousand workers who were involved in cleaning up the site and its surroundings received fractionated exposure, primarily from external γ radiation. To increase our understanding of the role of protracted low-dose radiation exposure in the etiology of leukemia, we conducted a nested case-control study of leukemia in a cohort of cleanup workers identified from the Chornobyl State Registry of Ukraine. The analysis is based on 71 cases of histologically confirmed leukemia diagnosed in 1986–2000 and 501 age- and residence-matched controls selected from the same cohort. Study subjects or their proxies were interviewed about their cleanup activities and other relevant factors. Individual bone marrow radiation doses were estimated by the RADRUE dose reconstruction method (mean dose = 76.4 mGy, SD = 213.4). We used conditional logistic regression to estimate leukemia risks. The excess relative risk (ERR) of total leukemia was 3.44 per Gy [95% confidence interval (CI) 0.47–9.78, P < 0.01]. The dose response was linear and did not differ significantly by calendar period of first work in the 30-km Chornobyl zone, duration or type of work. We found a similar dose–response relationship for chronic and non-chronic lymphocytic leukemia [ERR = 4.09 per Gy (95% CI < 0–14.41) and 2.73 per Gy (95% CI < 0–13.50), respectively]. To further clarify these issues, we are extending the case-control study to ascertain cases for another 6 years (2001–2006).</abstract><cop>United States</cop><pub>Radiation Research Society</pub><pmid>19138038</pmid><doi>10.1667/RR1404.1</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Radiation research, 2008-12, Vol.170 (6), p.711-720 |
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| subjects | Adult Age Distribution Aged Case-Control Studies Chernobyl Nuclear Accident Chronic lymphocytic leukemia Cohort Studies Dose response relationship Dosimetry Environmental Restoration and Remediation Humans Ionizing radiation Leukemia Leukemia - epidemiology Leukemia - etiology Leukemia - pathology Logistic Models Male Membrane Proteins Middle Aged Neoplasms, Radiation-Induced - epidemiology Occupational Exposure P values Proxy reporting Proxy statements Radiation Dosage Radiation dose response relationship REGULAR ARTICLES Risk Assessment Time Factors Tumor Suppressor Proteins Ukraine - epidemiology United States |
| title | The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: III. Radiation Risks |
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