The Behavior of the Hydrophobic Effect under Pressure and Protein Denaturation

It is well known that proteins denature under high pressure. The mechanism that underlies such a process is still not clearly understood, however, giving way to controversial interpretations. Using molecular dynamics simulation on systems that may be regarded experimentally as limiting examples of t...

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Veröffentlicht in:Biophysical journal 2010-04, Vol.98 (8), p.1626-1631
Hauptverfasser: Grigera, J. Raúl, McCarthy, Andres N.
Format: Artikel
Sprache:eng
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