A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival

Rac1 and Rac2 GTPases transduce signals from multiple receptors leading to cell migration, adhesion, proliferation, and survival. In the absence of Rac1 and Rac2, B cell development is arrested at an IgD- transitional B cell stage that we term transitional type 0 (T0). We show that T0 cells cannot e...

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Veröffentlicht in:	The Journal of experimental medicine 2010-04, Vol.207 (4), p.837-853
Hauptverfasser:	Henderson, Robert B, Grys, Katarzyna, Vehlow, Anne, de Bettignies, Carine, Zachacz, Agnieszka, Henley, Tom, Turner, Martin, Batista, Facundo, Tybulewicz, Victor L J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - immunology Antibodies - pharmacology Antigens, CD - metabolism B-Lymphocyte Subsets - cytology B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism B-Lymphocytes - cytology B-Lymphocytes - immunology B-Lymphocytes - metabolism bcl-X Protein - genetics Bone Marrow Cells - cytology Bone Marrow Cells - immunology Cell Adhesion - genetics Cell Adhesion - immunology Cell Differentiation - drug effects Cell Differentiation - immunology Cell Movement - drug effects Cell Proliferation Cell Survival - genetics Chemokines - pharmacology Immunoglobulin D - metabolism Integrins - antagonists & inhibitors Integrins - immunology Integrins - metabolism Intracellular Signaling Peptides and Proteins - genetics Lymphocyte Function-Associated Antigen-1 - metabolism Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Mice, Transgenic Neuropeptides - genetics Pertussis Toxin - pharmacology Protein-Tyrosine Kinases - genetics Proto-Oncogene Proteins c-vav - genetics rac GTP-Binding Proteins - genetics rac GTP-Binding Proteins - metabolism rac1 GTP-Binding Protein RAC2 GTP-Binding Protein rap1 GTP-Binding Proteins - metabolism Receptors, Chemokine - antagonists & inhibitors Receptors, Chemokine - metabolism Receptors, CXCR4 - antagonists & inhibitors Signal Transduction - drug effects Signal Transduction - immunology Spleen - cytology Spleen - immunology Syk Kinase
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