A Semisynthesis Platform for Investigating Structure−Function Relationships in the N-Terminal Domain of the Anthrax Lethal Factor

Many bacterial toxins act by covalently altering molecular targets within the cytosol of mammalian cells and therefore must transport their catalytic moieties across a membrane. The Protective-Antigen (PA) moiety of anthrax toxin forms multimeric pores that transport the two enzymatic moieties, the...

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Veröffentlicht in:	ACS chemical biology 2010-04, Vol.5 (4), p.359-364
Hauptverfasser:	Pentelute, Brad L, Barker, Adam P, Janowiak, Blythe E, Kent, Stephen B. H, Collier, R. John
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anthrax - metabolism Antigens, Bacterial - chemistry Antigens, Bacterial - metabolism Bacillus anthracis - chemistry Bacillus anthracis - metabolism Bacterial Toxins - chemical synthesis Bacterial Toxins - chemistry Bacterial Toxins - metabolism Ions - metabolism Lipid Bilayers - metabolism Models, Molecular Molecular Sequence Data Protein Folding Protein Structure, Tertiary
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