House Dust Concentrations of Organophosphate Flame Retardants in Relation to Hormone Levels and Semen Quality Parameters
Background: Organophosphate (OP) compounds, such as tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP), are commonly used as additive flame retardants and plasticizers in a wide range of materials. Although widespread human exposure to OP flame retardants is likely, there is...
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| Veröffentlicht in: | Environmental health perspectives 2010-03, Vol.118 (3), p.318-323 |
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| description | Background: Organophosphate (OP) compounds, such as tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP), are commonly used as additive flame retardants and plasticizers in a wide range of materials. Although widespread human exposure to OP flame retardants is likely, there is a lack of human and animal data on potential health effects. Objective: We explored relationships of TDCPP and TPP concentrations in house dust with hormone levels and semen quality parameters. Methods: We analyzed house dust from 50 men recruited through a U.S. infertility clinic for TDCPP and TPP. Relationships with reproductive and thyroid hormone levels, as well as semen quality parameters, were assessed using crude and multivariable linear regression. Results: TDCPP and TPP were detected in 96% and 98% of samples, respectively, with widely varying concentrations up to 1.8 mg/g. In models adjusted for age and body mass index, an inter-quartile range (IQR) increase in TDCPP was associated with a 3% [95% confidence interval (CI), -5% to -1%) decline in free thyroxine and a 17% (95% CI, 4-32%) increase in prolactin. There was a suggestive inverse association between TDCPP and free androgen index that became less evident in adjusted models. In the adjusted models, an IQR increase in TPP was associated with a 10% (95% CI, 2-19%) increase in prolactin and a 19% (95% CI, -30% to -5%) decrease in sperm concentration. Conclusion: OP flame retardants may be associated with altered hormone levels and decreased semen quality in men. More research on sources and levels of human exposure to OP flame retardants and associated health outcomes are needed. |
| doi_str_mv | 10.1289/ehp.0901332 |
| format | Article |
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Although widespread human exposure to OP flame retardants is likely, there is a lack of human and animal data on potential health effects. Objective: We explored relationships of TDCPP and TPP concentrations in house dust with hormone levels and semen quality parameters. Methods: We analyzed house dust from 50 men recruited through a U.S. infertility clinic for TDCPP and TPP. Relationships with reproductive and thyroid hormone levels, as well as semen quality parameters, were assessed using crude and multivariable linear regression. Results: TDCPP and TPP were detected in 96% and 98% of samples, respectively, with widely varying concentrations up to 1.8 mg/g. In models adjusted for age and body mass index, an inter-quartile range (IQR) increase in TDCPP was associated with a 3% [95% confidence interval (CI), -5% to -1%) decline in free thyroxine and a 17% (95% CI, 4-32%) increase in prolactin. There was a suggestive inverse association between TDCPP and free androgen index that became less evident in adjusted models. In the adjusted models, an IQR increase in TPP was associated with a 10% (95% CI, 2-19%) increase in prolactin and a 19% (95% CI, -30% to -5%) decrease in sperm concentration. Conclusion: OP flame retardants may be associated with altered hormone levels and decreased semen quality in men. More research on sources and levels of human exposure to OP flame retardants and associated health outcomes are needed.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.0901332</identifier><identifier>PMID: 20194068</identifier><identifier>CODEN: EVHPAZ</identifier><language>eng</language><publisher>Research Triangle Park, NC: National Institute of Environmental Health Sciences</publisher><subject>Adolescent ; Adult ; Air Pollutants - analysis ; Air Pollutants - toxicity ; Biological and medical sciences ; Birth control ; Chemical hazards ; Dust - analysis ; Environmental agencies ; Environmental aspects ; Environmental health ; Epidemiology ; Flame retardants ; Flame Retardants - analysis ; Flame Retardants - toxicity ; Gynecology. Andrology. Obstetrics ; Halogenated diphenyl ethers ; Health aspects ; Hormones ; Hormones - blood ; Hormones - metabolism ; Humans ; Male ; Medical sciences ; Men ; Methods ; Middle Aged ; Organophosphates - analysis ; Organophosphates - toxicity ; Organophosphorus compounds ; Organophosphorus Compounds - analysis ; Organophosphorus Compounds - toxicity ; Phosphates ; Phosphites - analysis ; Phosphites - toxicity ; Phosphoric acid esters ; Physiological aspects ; Semen ; Semen - cytology ; Semen - drug effects ; Semen analysis ; Sperm Count ; Spermatozoa ; Sterility. Assisted procreation ; Young Adult</subject><ispartof>Environmental health perspectives, 2010-03, Vol.118 (3), p.318-323</ispartof><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Mar 2010</rights><rights>2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c729t-a456400ac91adc09315b6e4a1e1a4eb38a7f5fb40924eafc602b8be40bdc67973</citedby><cites>FETCH-LOGICAL-c729t-a456400ac91adc09315b6e4a1e1a4eb38a7f5fb40924eafc602b8be40bdc67973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25615023$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25615023$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,728,781,785,804,865,886,27929,27930,53796,53798,58022,58255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22486158$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20194068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meeker, John D.</creatorcontrib><creatorcontrib>Stapleton, Heather M.</creatorcontrib><title>House Dust Concentrations of Organophosphate Flame Retardants in Relation to Hormone Levels and Semen Quality Parameters</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Background: Organophosphate (OP) compounds, such as tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP), are commonly used as additive flame retardants and plasticizers in a wide range of materials. Although widespread human exposure to OP flame retardants is likely, there is a lack of human and animal data on potential health effects. Objective: We explored relationships of TDCPP and TPP concentrations in house dust with hormone levels and semen quality parameters. Methods: We analyzed house dust from 50 men recruited through a U.S. infertility clinic for TDCPP and TPP. Relationships with reproductive and thyroid hormone levels, as well as semen quality parameters, were assessed using crude and multivariable linear regression. Results: TDCPP and TPP were detected in 96% and 98% of samples, respectively, with widely varying concentrations up to 1.8 mg/g. In models adjusted for age and body mass index, an inter-quartile range (IQR) increase in TDCPP was associated with a 3% [95% confidence interval (CI), -5% to -1%) decline in free thyroxine and a 17% (95% CI, 4-32%) increase in prolactin. There was a suggestive inverse association between TDCPP and free androgen index that became less evident in adjusted models. In the adjusted models, an IQR increase in TPP was associated with a 10% (95% CI, 2-19%) increase in prolactin and a 19% (95% CI, -30% to -5%) decrease in sperm concentration. Conclusion: OP flame retardants may be associated with altered hormone levels and decreased semen quality in men. More research on sources and levels of human exposure to OP flame retardants and associated health outcomes are needed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Air Pollutants - analysis</subject><subject>Air Pollutants - toxicity</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Chemical hazards</subject><subject>Dust - analysis</subject><subject>Environmental agencies</subject><subject>Environmental aspects</subject><subject>Environmental health</subject><subject>Epidemiology</subject><subject>Flame retardants</subject><subject>Flame Retardants - analysis</subject><subject>Flame Retardants - toxicity</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Halogenated diphenyl ethers</subject><subject>Health aspects</subject><subject>Hormones</subject><subject>Hormones - blood</subject><subject>Hormones - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Organophosphates - analysis</subject><subject>Organophosphates - toxicity</subject><subject>Organophosphorus compounds</subject><subject>Organophosphorus Compounds - analysis</subject><subject>Organophosphorus Compounds - toxicity</subject><subject>Phosphates</subject><subject>Phosphites - analysis</subject><subject>Phosphites - toxicity</subject><subject>Phosphoric acid esters</subject><subject>Physiological aspects</subject><subject>Semen</subject><subject>Semen - cytology</subject><subject>Semen - drug effects</subject><subject>Semen analysis</subject><subject>Sperm Count</subject><subject>Spermatozoa</subject><subject>Sterility. 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Assisted procreation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meeker, John D.</creatorcontrib><creatorcontrib>Stapleton, Heather M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Engineering Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meeker, John D.</au><au>Stapleton, Heather M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>House Dust Concentrations of Organophosphate Flame Retardants in Relation to Hormone Levels and Semen Quality Parameters</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>118</volume><issue>3</issue><spage>318</spage><epage>323</epage><pages>318-323</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><coden>EVHPAZ</coden><abstract>Background: Organophosphate (OP) compounds, such as tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP), are commonly used as additive flame retardants and plasticizers in a wide range of materials. Although widespread human exposure to OP flame retardants is likely, there is a lack of human and animal data on potential health effects. Objective: We explored relationships of TDCPP and TPP concentrations in house dust with hormone levels and semen quality parameters. Methods: We analyzed house dust from 50 men recruited through a U.S. infertility clinic for TDCPP and TPP. Relationships with reproductive and thyroid hormone levels, as well as semen quality parameters, were assessed using crude and multivariable linear regression. Results: TDCPP and TPP were detected in 96% and 98% of samples, respectively, with widely varying concentrations up to 1.8 mg/g. In models adjusted for age and body mass index, an inter-quartile range (IQR) increase in TDCPP was associated with a 3% [95% confidence interval (CI), -5% to -1%) decline in free thyroxine and a 17% (95% CI, 4-32%) increase in prolactin. There was a suggestive inverse association between TDCPP and free androgen index that became less evident in adjusted models. In the adjusted models, an IQR increase in TPP was associated with a 10% (95% CI, 2-19%) increase in prolactin and a 19% (95% CI, -30% to -5%) decrease in sperm concentration. Conclusion: OP flame retardants may be associated with altered hormone levels and decreased semen quality in men. More research on sources and levels of human exposure to OP flame retardants and associated health outcomes are needed.</abstract><cop>Research Triangle Park, NC</cop><pub>National Institute of Environmental Health Sciences</pub><pmid>20194068</pmid><doi>10.1289/ehp.0901332</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Air Pollutants - analysis Air Pollutants - toxicity Biological and medical sciences Birth control Chemical hazards Dust - analysis Environmental agencies Environmental aspects Environmental health Epidemiology Flame retardants Flame Retardants - analysis Flame Retardants - toxicity Gynecology. Andrology. Obstetrics Halogenated diphenyl ethers Health aspects Hormones Hormones - blood Hormones - metabolism Humans Male Medical sciences Men Methods Middle Aged Organophosphates - analysis Organophosphates - toxicity Organophosphorus compounds Organophosphorus Compounds - analysis Organophosphorus Compounds - toxicity Phosphates Phosphites - analysis Phosphites - toxicity Phosphoric acid esters Physiological aspects Semen Semen - cytology Semen - drug effects Semen analysis Sperm Count Spermatozoa Sterility. Assisted procreation Young Adult |
| title | House Dust Concentrations of Organophosphate Flame Retardants in Relation to Hormone Levels and Semen Quality Parameters |
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