Nonactin biosynthesis: Setting limits on what can be achieved with precursor-directed biosynthesis

Nonactin, produced by Streptomyces griseus ETH A7796, is a macrotetrolide assembled from nonactic acid. It is an effective inhibitor of drug efflux in multidrug resistant erythroleukemia K562 cells at sub-toxic concentrations and has been shown to possess both antibacterial and antitumor activity. A...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-02, Vol.19 (4), p.1233-1235
Hauptverfasser:	Kusche, Brian R., Phillips, Joshua B., Priestley, Nigel D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Biosynthesis Drug Resistance, Multiple, Bacterial - drug effects Inhibitory Concentration 50 Macrolides - chemical synthesis Macrolides - chemistry Macrolides - pharmacology Molecular Structure Nonactin Precursor-directed Streptomyces griseus Streptomyces griseus - chemistry Streptomyces griseus - metabolism
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