Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome–negative myeloproliferative neoplasms

Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs) including polycythemia vera, essential thrombocythemia, and primary myelofibrosis show an inherent tendency for transformation into leukemia (MPN-blast phase), which is hypothesized to be accompanied by acquisition of additional ge...

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Veröffentlicht in:	Blood 2010-04, Vol.115 (14), p.2882-2890
Hauptverfasser:	Thoennissen, Nils H., Krug, Utz O., Lee, Dhong Hyun Tony, Kawamata, Norihiko, Iwanski, Gabriela B., Lasho, Terra, Weiss, Tamara, Nowak, Daniel, Koren-Michowitz, Maya, Kato, Motohiro, Sanada, Masashi, Shih, Lee-Yung, Nagler, Arnon, Raynaud, Sophie D., Müller-Tidow, Carsten, Mesa, Ruben, Haferlach, Torsten, Gilliland, D. Gary, Tefferi, Ayalew, Ogawa, Seishi, Koeffler, H. Phillip
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Blast Crisis - genetics Blast Crisis - metabolism Blast Crisis - mortality Chromosomes, Human - genetics Chromosomes, Human - metabolism Disease-Free Survival Female Hematologic Neoplasms - genetics Hematologic Neoplasms - metabolism Hematologic Neoplasms - mortality Humans Janus Kinase 2 - genetics Janus Kinase 2 - metabolism Loss of Heterozygosity Male Middle Aged Myeloid Neoplasia Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Philadelphia Chromosome Prevalence Survival Rate
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