Changes in thioredoxin concentrations: an observation in an ultra-marathon race
Changes in plasma thioredoxin (TRX) concentrations before, during, and after a 130-km endurance race were measured with the aim of elucidating the relationship between exercise and oxidative stress (OS). Blood samples were taken from 18 runners participating in a 2-day-long 130-km ultra-marathon dur...
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| Veröffentlicht in: | Environmental health and preventive medicine 2010-05, Vol.15 (3), p.129-134 |
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| creator | MARUMOTO, Mitsuhiro SUZUKI, Sadao KOBAYASHI, Masaaki YODOI, Junji TOKUDOME, Shinkan HOSONO, Akihiro ARAKAWA, Kazuyuki SHIBATA, Kiyoshi FUKU, Mizuho GOTO, Chiho TOKUDOME, Yuko HOSHINO, Hideki IMAEDA, Nahomi |
| description | Changes in plasma thioredoxin (TRX) concentrations before, during, and after a 130-km endurance race were measured with the aim of elucidating the relationship between exercise and oxidative stress (OS).
Blood samples were taken from 18 runners participating in a 2-day-long 130-km ultra-marathon during the 2 days of the race and for 1 week thereafter. There were six sampling time points: at baseline, after the goal had been reached on the first and second day of the endurance race, respectively, and on 1, 3, and 5/6 days post-endurance race. The samples were analyzed for plasma TRX concentrations, platelet count, and blood lipid profiles.
Concentrations of plasma TRX increased from 17.9 ± 1.2 ng/mL (mean ± standard error of the mean) at baseline to 57.3 ± 5.0 ng/mL after the first day's goal had been reached and to 70.1 ± 6.9 ng/mL after the second day's goal had been reached; it then returned to the baseline level 1 day after the race. Platelet counts of 21.3 ± 1.2 × 10(4) cell/μL at baseline increased to 23.9 ± 1.5 × 10(4) cells/μL on Day 1 and to 26.1 ± 1.0 × 10(4) cells/μL on Day 2. On Day 7, the platelet counts had fallen to 22.1 ± 1.2 × 10(4) cell/μL. There was a significant positive correlation between plasma TRX and platelet count.
These data suggest that plasma TRX is an OS marker during physical exercise. Further studies are needed to determine the appropriate level of exercise for the promotion of health. |
| doi_str_mv | 10.1007/s12199-009-0119-4 |
| format | Article |
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Blood samples were taken from 18 runners participating in a 2-day-long 130-km ultra-marathon during the 2 days of the race and for 1 week thereafter. There were six sampling time points: at baseline, after the goal had been reached on the first and second day of the endurance race, respectively, and on 1, 3, and 5/6 days post-endurance race. The samples were analyzed for plasma TRX concentrations, platelet count, and blood lipid profiles.
Concentrations of plasma TRX increased from 17.9 ± 1.2 ng/mL (mean ± standard error of the mean) at baseline to 57.3 ± 5.0 ng/mL after the first day's goal had been reached and to 70.1 ± 6.9 ng/mL after the second day's goal had been reached; it then returned to the baseline level 1 day after the race. Platelet counts of 21.3 ± 1.2 × 10(4) cell/μL at baseline increased to 23.9 ± 1.5 × 10(4) cells/μL on Day 1 and to 26.1 ± 1.0 × 10(4) cells/μL on Day 2. On Day 7, the platelet counts had fallen to 22.1 ± 1.2 × 10(4) cell/μL. There was a significant positive correlation between plasma TRX and platelet count.
These data suggest that plasma TRX is an OS marker during physical exercise. Further studies are needed to determine the appropriate level of exercise for the promotion of health.</description><identifier>ISSN: 1342-078X</identifier><identifier>EISSN: 1347-4715</identifier><identifier>DOI: 10.1007/s12199-009-0119-4</identifier><identifier>PMID: 19960374</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Biological and medical sciences ; Blood platelets ; Environmental health ; Enzymes ; Fundamental and applied biological sciences. Psychology ; Lipids ; Marathons ; Oxidation ; Regular ; Running ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><ispartof>Environmental health and preventive medicine, 2010-05, Vol.15 (3), p.129-134</ispartof><rights>2015 INIST-CNRS</rights><rights>The Japanese Society for Hygiene 2010</rights><rights>The Japanese Society for Hygiene 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5214-bfb1c135f85239d2d2183dafa1d5004521837c5c2716cc522c7d746e5ba49b643</citedby><cites>FETCH-LOGICAL-c5214-bfb1c135f85239d2d2183dafa1d5004521837c5c2716cc522c7d746e5ba49b643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854340/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854340/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22812849$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19960374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MARUMOTO, Mitsuhiro</creatorcontrib><creatorcontrib>SUZUKI, Sadao</creatorcontrib><creatorcontrib>KOBAYASHI, Masaaki</creatorcontrib><creatorcontrib>YODOI, Junji</creatorcontrib><creatorcontrib>TOKUDOME, Shinkan</creatorcontrib><creatorcontrib>HOSONO, Akihiro</creatorcontrib><creatorcontrib>ARAKAWA, Kazuyuki</creatorcontrib><creatorcontrib>SHIBATA, Kiyoshi</creatorcontrib><creatorcontrib>FUKU, Mizuho</creatorcontrib><creatorcontrib>GOTO, Chiho</creatorcontrib><creatorcontrib>TOKUDOME, Yuko</creatorcontrib><creatorcontrib>HOSHINO, Hideki</creatorcontrib><creatorcontrib>IMAEDA, Nahomi</creatorcontrib><title>Changes in thioredoxin concentrations: an observation in an ultra-marathon race</title><title>Environmental health and preventive medicine</title><addtitle>Environ Health Prev Med</addtitle><description>Changes in plasma thioredoxin (TRX) concentrations before, during, and after a 130-km endurance race were measured with the aim of elucidating the relationship between exercise and oxidative stress (OS).
Blood samples were taken from 18 runners participating in a 2-day-long 130-km ultra-marathon during the 2 days of the race and for 1 week thereafter. There were six sampling time points: at baseline, after the goal had been reached on the first and second day of the endurance race, respectively, and on 1, 3, and 5/6 days post-endurance race. The samples were analyzed for plasma TRX concentrations, platelet count, and blood lipid profiles.
Concentrations of plasma TRX increased from 17.9 ± 1.2 ng/mL (mean ± standard error of the mean) at baseline to 57.3 ± 5.0 ng/mL after the first day's goal had been reached and to 70.1 ± 6.9 ng/mL after the second day's goal had been reached; it then returned to the baseline level 1 day after the race. Platelet counts of 21.3 ± 1.2 × 10(4) cell/μL at baseline increased to 23.9 ± 1.5 × 10(4) cells/μL on Day 1 and to 26.1 ± 1.0 × 10(4) cells/μL on Day 2. On Day 7, the platelet counts had fallen to 22.1 ± 1.2 × 10(4) cell/μL. There was a significant positive correlation between plasma TRX and platelet count.
These data suggest that plasma TRX is an OS marker during physical exercise. Further studies are needed to determine the appropriate level of exercise for the promotion of health.</description><subject>Biological and medical sciences</subject><subject>Blood platelets</subject><subject>Environmental health</subject><subject>Enzymes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lipids</subject><subject>Marathons</subject><subject>Oxidation</subject><subject>Regular</subject><subject>Running</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. 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Blood samples were taken from 18 runners participating in a 2-day-long 130-km ultra-marathon during the 2 days of the race and for 1 week thereafter. There were six sampling time points: at baseline, after the goal had been reached on the first and second day of the endurance race, respectively, and on 1, 3, and 5/6 days post-endurance race. The samples were analyzed for plasma TRX concentrations, platelet count, and blood lipid profiles.
Concentrations of plasma TRX increased from 17.9 ± 1.2 ng/mL (mean ± standard error of the mean) at baseline to 57.3 ± 5.0 ng/mL after the first day's goal had been reached and to 70.1 ± 6.9 ng/mL after the second day's goal had been reached; it then returned to the baseline level 1 day after the race. Platelet counts of 21.3 ± 1.2 × 10(4) cell/μL at baseline increased to 23.9 ± 1.5 × 10(4) cells/μL on Day 1 and to 26.1 ± 1.0 × 10(4) cells/μL on Day 2. On Day 7, the platelet counts had fallen to 22.1 ± 1.2 × 10(4) cell/μL. There was a significant positive correlation between plasma TRX and platelet count.
These data suggest that plasma TRX is an OS marker during physical exercise. Further studies are needed to determine the appropriate level of exercise for the promotion of health.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>19960374</pmid><doi>10.1007/s12199-009-0119-4</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Biological and medical sciences Blood platelets Environmental health Enzymes Fundamental and applied biological sciences. Psychology Lipids Marathons Oxidation Regular Running Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports |
| title | Changes in thioredoxin concentrations: an observation in an ultra-marathon race |
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