unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI

Insight into protein structure and function is best obtained through a synthesis of experimental, structural and bioinformatic data. Here, we outline a framework that we call MUSE (mutual information, unigenic evolution and structure-guided elucidation), which facilitated the identification of previ...

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Veröffentlicht in:	Nucleic acids research 2010-04, Vol.38 (7), p.2411-2427
Hauptverfasser:	Kleinstiver, Benjamin P, Fernandes, Andrew D, Gloor, Gregory B, Edgell, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Catalytic Domain Computational Biology - methods Data Interpretation, Statistical DNA Cleavage Endodeoxyribonucleases - chemistry Endodeoxyribonucleases - genetics Endodeoxyribonucleases - metabolism Evolution, Molecular Models, Molecular Mutagenesis, Site-Directed Mutation Nucleic Acid Enzymes Protein Structure, Tertiary Sequence Alignment
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