Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

During carcinogenesis of pancreatic islets in transgenic mice, an angiogenic switch activates the quiescent vasculature. Paradoxically, vascular endothelial growth factor (VEGF) and its receptors are expressed constitutively. Nevertheless, a synthetic inhibitor (SU5416) of VEGF signalling impairs an...

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Veröffentlicht in:	Nature cell biology 2000-10, Vol.2 (10), p.737-744
Hauptverfasser:	Hanahan, Douglas, Bergers, Gabriele, Brekken, Rolf, McMahon, Gerald, Vu, Thiennu H, Itoh, Takeshi, Tamaki, Kazuhiko, Tanzawa, Kazuhiko, Thorpe, Philip, Itohara, Shigeyoshi, Werb, Zena
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - pharmacology Angiogenesis Animals Biomedical and Life Sciences Cancer Cancer Research Carcinogenesis Cell Biology Cell Transformation, Neoplastic Developmental Biology Endothelial Growth Factors - isolation & purification Genes, Switch Genetic aspects Islets of Langerhans - pathology Lesions Life Sciences Lymphokines - isolation & purification Matrix Metalloproteinase 9 - metabolism Metalloproteins Mice Mice, Transgenic Neovascularization Neovascularization, Pathologic Pancreatic Neoplasms - blood supply Physiological aspects Receptor Protein-Tyrosine Kinases - isolation & purification Receptors, Growth Factor - isolation & purification Receptors, Vascular Endothelial Growth Factor Signal Transduction Stem Cells Tissue Distribution Transgenic animals Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Vascular endothelium
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