Activity in Preserved Left Hemisphere Regions Predicts Anomia Severity in Aphasia
Understanding the neural mechanism that supports preserved language processing in aphasia has implications for both basic and applied science. This study examined brain activation associated with correct picture naming in 15 patients with aphasia. We contrasted each patient's activation to the...
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| Veröffentlicht in: | Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2010-05, Vol.20 (5), p.1013-1019 |
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| container_title | Cerebral cortex (New York, N.Y. 1991) |
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| creator | Fridriksson, Julius Bonilha, Leonardo Baker, Julie M. Moser, Dana Rorden, Chris |
| description | Understanding the neural mechanism that supports preserved language processing in aphasia has implications for both basic and applied science. This study examined brain activation associated with correct picture naming in 15 patients with aphasia. We contrasted each patient's activation to the activation observed in a neurologically healthy control group, allowing us to identify regions with unusual activity patterns. The results revealed that increased activation in preserved left hemisphere areas is associated with better naming performance in aphasia. This relationship was linear in nature; progressively less cortical activation was associated with greater severity of anomia. These findings are consistent with others who suggests that residual language function following stroke relies on preserved cortical areas in the left hemisphere. |
| doi_str_mv | 10.1093/cercor/bhp160 |
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This study examined brain activation associated with correct picture naming in 15 patients with aphasia. We contrasted each patient's activation to the activation observed in a neurologically healthy control group, allowing us to identify regions with unusual activity patterns. The results revealed that increased activation in preserved left hemisphere areas is associated with better naming performance in aphasia. This relationship was linear in nature; progressively less cortical activation was associated with greater severity of anomia. These findings are consistent with others who suggests that residual language function following stroke relies on preserved cortical areas in the left hemisphere.</description><identifier>ISSN: 1047-3211</identifier><identifier>EISSN: 1460-2199</identifier><identifier>DOI: 10.1093/cercor/bhp160</identifier><identifier>PMID: 19687294</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anomia - etiology ; Anomia - pathology ; Aphasia - complications ; Brain - blood supply ; Brain - physiopathology ; Brain Mapping ; brain plasticity ; Female ; fMRI ; Functional Laterality - physiology ; Humans ; Image Processing, Computer-Assisted - methods ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Names ; neuroimaging ; Neuropsychological Tests ; Oxygen - blood ; Pattern Recognition, Visual - physiology ; Photic Stimulation - methods ; Predictive Value of Tests ; recovery ; Regression Analysis ; stroke</subject><ispartof>Cerebral cortex (New York, N.Y. 1991), 2010-05, Vol.20 (5), p.1013-1019</ispartof><rights>The Author 2009. 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For permissions, please e-mail: journals.permissions@oxfordjournals.org 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-8486c02a86260bcb1d6b2cae3b197bb218b6f62bbec6cde07079a32e7559e9ec3</citedby><cites>FETCH-LOGICAL-c456t-8486c02a86260bcb1d6b2cae3b197bb218b6f62bbec6cde07079a32e7559e9ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19687294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fridriksson, Julius</creatorcontrib><creatorcontrib>Bonilha, Leonardo</creatorcontrib><creatorcontrib>Baker, Julie M.</creatorcontrib><creatorcontrib>Moser, Dana</creatorcontrib><creatorcontrib>Rorden, Chris</creatorcontrib><title>Activity in Preserved Left Hemisphere Regions Predicts Anomia Severity in Aphasia</title><title>Cerebral cortex (New York, N.Y. 1991)</title><addtitle>Cereb Cortex</addtitle><description>Understanding the neural mechanism that supports preserved language processing in aphasia has implications for both basic and applied science. This study examined brain activation associated with correct picture naming in 15 patients with aphasia. We contrasted each patient's activation to the activation observed in a neurologically healthy control group, allowing us to identify regions with unusual activity patterns. The results revealed that increased activation in preserved left hemisphere areas is associated with better naming performance in aphasia. This relationship was linear in nature; progressively less cortical activation was associated with greater severity of anomia. These findings are consistent with others who suggests that residual language function following stroke relies on preserved cortical areas in the left hemisphere.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anomia - etiology</subject><subject>Anomia - pathology</subject><subject>Aphasia - complications</subject><subject>Brain - blood supply</subject><subject>Brain - physiopathology</subject><subject>Brain Mapping</subject><subject>brain plasticity</subject><subject>Female</subject><subject>fMRI</subject><subject>Functional Laterality - physiology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Names</subject><subject>neuroimaging</subject><subject>Neuropsychological Tests</subject><subject>Oxygen - blood</subject><subject>Pattern Recognition, Visual - physiology</subject><subject>Photic Stimulation - methods</subject><subject>Predictive Value of Tests</subject><subject>recovery</subject><subject>Regression Analysis</subject><subject>stroke</subject><issn>1047-3211</issn><issn>1460-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLAzEUhYMoWh9LtzI7V6N5TJLJRijFWrHgq6K4CUnm1kbbmTGZFv33jrRYXbm6F853D_dwEDok-IRgxU4dBFeFUzupicAbqEMygVNKlNpsd5zJlFFCdtBujK8YE0k53UY7RIlcUpV10G3XNX7hm8_El8lNgAhhAUUyhHGTDGDmYz2BAMkdvPiqjN9E4V0Tk25ZzbxJ7mEBYXXdrScmerOPtsZmGuFgNffQQ_981Bukw-uLy153mLqMiybNs1w4TE0uqMDWWVIIS50BZomS1lKSWzEW1FpwwhWAJZbKMAqScwUKHNtDZ0vfem5nUDgom2Cmug5-ZsKnrozXf5XST_RLtdA055Rj3BocrwxC9T6H2Og2roPp1JRQzaOWmWBYZYz_TzLWZmIib8l0SbpQxRhg_PMPwfq7L73sSy_7avmj3yHW9KqgtaGPDXz86Ca8aSGZ5Hrw9Kyv-P1j_-5ipCn7AoMwpBw</recordid><startdate>20100501</startdate><enddate>20100501</enddate><creator>Fridriksson, Julius</creator><creator>Bonilha, Leonardo</creator><creator>Baker, Julie M.</creator><creator>Moser, Dana</creator><creator>Rorden, Chris</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20100501</creationdate><title>Activity in Preserved Left Hemisphere Regions Predicts Anomia Severity in Aphasia</title><author>Fridriksson, Julius ; 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| source | MEDLINE; Oxford University Press Journals Current; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adult Aged Aged, 80 and over Anomia - etiology Anomia - pathology Aphasia - complications Brain - blood supply Brain - physiopathology Brain Mapping brain plasticity Female fMRI Functional Laterality - physiology Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging - methods Male Middle Aged Names neuroimaging Neuropsychological Tests Oxygen - blood Pattern Recognition, Visual - physiology Photic Stimulation - methods Predictive Value of Tests recovery Regression Analysis stroke |
| title | Activity in Preserved Left Hemisphere Regions Predicts Anomia Severity in Aphasia |
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