Atherosclerosis induced by chronic inhibition of the synthesis of nitric oxide in moderately hypercholesterolaemic rabbits is suppressed by pitavastatin

Background and purpose: It is not clear if the new 3‐hydroxyl‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase inhibitor pitavastatin prevents atherogenesis by a direct effect. Statins have a cholesterol‐lowering effect, so an accessible animal model of atherosclerosis showing only moderate hypercho...

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Veröffentlicht in:	British journal of pharmacology 2010-04, Vol.159 (7), p.1418-1428
Hauptverfasser:	Kitahara, Masaki, Kanaki, Tatsuro, Ishii, Itsuko, Saito, Yasushi
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion Animals atherosclerosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - etiology Atherosclerosis - prevention & control Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cell Adhesion - drug effects Disorders of blood lipids. Hyperlipoproteinemia Endothelium, Vascular - cytology Enzyme Inhibitors - pharmacology Humans Hypercholesterolemia - complications Hypercholesterolemia - metabolism Immunohistochemistry lipid accumulation L‐NAME macrophages Male Medical sciences Metabolic diseases moderate hypercholesterolaemia Monocytes - cytology Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Pharmacology. Drug treatments pitavastatin Quinolines - pharmacology Rabbits Research Papers
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