Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation
Maintenance of ocular viability is one of the major impediments to successful whole-eye transplantation. This review provides a comprehensive understanding of the current literature to help guide future studies in order to overcome this hurdle. A systematic multistage review of published literature...
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| Veröffentlicht in: | British journal of ophthalmology 2009-09, Vol.93 (9), p.1134-1140 |
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| creator | Ellenberg, D Shi, J Jain, S Chang, J-H Ripps, H Brady, S Melhem, E R Lakkis, F Adamis, A Chen, D-F Ellis-Behnke, R Langer, R S Strittmatter, S M Azar, D T |
| description | Maintenance of ocular viability is one of the major impediments to successful whole-eye transplantation. This review provides a comprehensive understanding of the current literature to help guide future studies in order to overcome this hurdle. A systematic multistage review of published literature was performed. Three specific questions were addressed: (1) Is recovery of visual function following eye transplantation greater in cold-blooded vertebrates when compared with mammals? (2) Is outer retina function following enucleation and reperfusion improved compared with enucleation alone? (3) Following optic-nerve transection, is there a correlation between retinal ganglion cell (RGC) survival and either time after transection or proximity of the transection to the globe? In a majority of the studies performed in the literature, recovery of visual function can occur after whole-eye transplantation in cold-blooded vertebrates. Following enucleation (and reperfusion), outer retinal function is maintained from 4 to 9 h. RGC survival following optic-nerve transection is inversely related to both the time since transection and the proximity of transection to the globe. Lastly, neurotrophins can increase RGC survival following optic-nerve transection. This review of the literature suggests that the use of a donor eye is feasible for whole-eye transplantation. |
| doi_str_mv | 10.1136/bjo.2008.155267 |
| format | Article |
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This review provides a comprehensive understanding of the current literature to help guide future studies in order to overcome this hurdle. A systematic multistage review of published literature was performed. Three specific questions were addressed: (1) Is recovery of visual function following eye transplantation greater in cold-blooded vertebrates when compared with mammals? (2) Is outer retina function following enucleation and reperfusion improved compared with enucleation alone? (3) Following optic-nerve transection, is there a correlation between retinal ganglion cell (RGC) survival and either time after transection or proximity of the transection to the globe? In a majority of the studies performed in the literature, recovery of visual function can occur after whole-eye transplantation in cold-blooded vertebrates. Following enucleation (and reperfusion), outer retinal function is maintained from 4 to 9 h. RGC survival following optic-nerve transection is inversely related to both the time since transection and the proximity of transection to the globe. Lastly, neurotrophins can increase RGC survival following optic-nerve transection. This review of the literature suggests that the use of a donor eye is feasible for whole-eye transplantation.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.2008.155267</identifier><identifier>PMID: 19286686</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cold ; Diabetic retinopathy ; Eye - physiopathology ; Eye - transplantation ; Eye Enucleation - adverse effects ; Mammals ; Medical research ; Medical sciences ; Miscellaneous ; National libraries ; Ophthalmology ; Optic nerve ; Optic Nerve Injuries - complications ; Optic Nerve Injuries - physiopathology ; Researchers ; Retina ; Retina - physiology ; Retinal Ganglion Cells - physiology ; Rodents ; Tissue Donors ; Tissue Survival - physiology ; Transplants & implants ; Vertebrates ; Visual Acuity</subject><ispartof>British journal of ophthalmology, 2009-09, Vol.93 (9), p.1134-1140</ispartof><rights>BMJ Publishing Group Ltd. All rights reserved.</rights><rights>2009 INIST-CNRS</rights><rights>Copyright: 2009 BMJ Publishing Group Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b522t-f1f3bab2a977a01abfbe80c38cb2f4f955dbafdbf7a10177a87aed2451e52b5f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bjo.bmj.com/content/93/9/1134.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://bjo.bmj.com/content/93/9/1134.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,315,728,781,785,793,886,3197,23573,27924,27926,27927,53793,53795,77602,77633</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21836138$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19286686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ellenberg, D</creatorcontrib><creatorcontrib>Shi, J</creatorcontrib><creatorcontrib>Jain, S</creatorcontrib><creatorcontrib>Chang, J-H</creatorcontrib><creatorcontrib>Ripps, H</creatorcontrib><creatorcontrib>Brady, S</creatorcontrib><creatorcontrib>Melhem, E R</creatorcontrib><creatorcontrib>Lakkis, F</creatorcontrib><creatorcontrib>Adamis, A</creatorcontrib><creatorcontrib>Chen, D-F</creatorcontrib><creatorcontrib>Ellis-Behnke, R</creatorcontrib><creatorcontrib>Langer, R S</creatorcontrib><creatorcontrib>Strittmatter, S M</creatorcontrib><creatorcontrib>Azar, D T</creatorcontrib><title>Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>Maintenance of ocular viability is one of the major impediments to successful whole-eye transplantation. This review provides a comprehensive understanding of the current literature to help guide future studies in order to overcome this hurdle. A systematic multistage review of published literature was performed. Three specific questions were addressed: (1) Is recovery of visual function following eye transplantation greater in cold-blooded vertebrates when compared with mammals? (2) Is outer retina function following enucleation and reperfusion improved compared with enucleation alone? (3) Following optic-nerve transection, is there a correlation between retinal ganglion cell (RGC) survival and either time after transection or proximity of the transection to the globe? In a majority of the studies performed in the literature, recovery of visual function can occur after whole-eye transplantation in cold-blooded vertebrates. Following enucleation (and reperfusion), outer retinal function is maintained from 4 to 9 h. RGC survival following optic-nerve transection is inversely related to both the time since transection and the proximity of transection to the globe. Lastly, neurotrophins can increase RGC survival following optic-nerve transection. This review of the literature suggests that the use of a donor eye is feasible for whole-eye transplantation.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cold</subject><subject>Diabetic retinopathy</subject><subject>Eye - physiopathology</subject><subject>Eye - transplantation</subject><subject>Eye Enucleation - adverse effects</subject><subject>Mammals</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>National libraries</subject><subject>Ophthalmology</subject><subject>Optic nerve</subject><subject>Optic Nerve Injuries - complications</subject><subject>Optic Nerve Injuries - physiopathology</subject><subject>Researchers</subject><subject>Retina</subject><subject>Retina - physiology</subject><subject>Retinal Ganglion Cells - physiology</subject><subject>Rodents</subject><subject>Tissue Donors</subject><subject>Tissue Survival - physiology</subject><subject>Transplants & implants</subject><subject>Vertebrates</subject><subject>Visual Acuity</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkUuP0zAUhS0EYjoDa3YoEmIWSOnYTv0ICySoGBhRwQbYWrZrDy5OHGyn0H-PS6Ly2LCyrPudo3vuAeARgkuEGnqldmGJIeRLRAim7A5YoBXlNYasvQsWEEJWI0TRGThPaVe-mCJ2H5yhFnNKOV0Ac9MNZus60-dU5VCZg6lylH0avOyzzC70z6ugRy9jtXdSOe_yobLB-_Dd9bdVGLLTdW_iftYZfdRUIVamH7U3vywegHtW-mQezu8F-HT9-uP6bb358OZm_XJTK4Jxri2yjZIKy5YxCZFUVhkOdcO1wnZlW0K2StqtskwiiArDmTRbvCLIEKyIbS7Ai8l3GFVntrqkitKLIbpOxoMI0om_J737Im7DXmBOIGa8GFzOBjF8G03KonNJG1-OYcKYBGWkbdsVLuCTf8BdGGNfwomyGG8bDFtYqKuJ0jGkFI09rYKgOBYoSoHiWKCYCiyKx38m-M3PjRXg6QzIpKW35ebapROHEW8oao5J6olzKZsfp7mMX0uIhhHx_vNaXL8iuNlwLt4V_tnEq2733y1_AiW6w9Y</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Ellenberg, D</creator><creator>Shi, J</creator><creator>Jain, S</creator><creator>Chang, J-H</creator><creator>Ripps, H</creator><creator>Brady, S</creator><creator>Melhem, E R</creator><creator>Lakkis, F</creator><creator>Adamis, A</creator><creator>Chen, D-F</creator><creator>Ellis-Behnke, R</creator><creator>Langer, R S</creator><creator>Strittmatter, S M</creator><creator>Azar, D T</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090901</creationdate><title>Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation</title><author>Ellenberg, D ; 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RGC survival following optic-nerve transection is inversely related to both the time since transection and the proximity of transection to the globe. Lastly, neurotrophins can increase RGC survival following optic-nerve transection. This review of the literature suggests that the use of a donor eye is feasible for whole-eye transplantation.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>19286686</pmid><doi>10.1136/bjo.2008.155267</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Cold Diabetic retinopathy Eye - physiopathology Eye - transplantation Eye Enucleation - adverse effects Mammals Medical research Medical sciences Miscellaneous National libraries Ophthalmology Optic nerve Optic Nerve Injuries - complications Optic Nerve Injuries - physiopathology Researchers Retina Retina - physiology Retinal Ganglion Cells - physiology Rodents Tissue Donors Tissue Survival - physiology Transplants & implants Vertebrates Visual Acuity |
| title | Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation |
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