Polysome trafficking of transcripts and microRNAs in regenerating liver after partial hepatectomy

Liver regeneration after 70% partial hepatectomy (PH) in rats induces >95% of hepatocytes to undergo two rounds of semisynchronous cell replication. Gene expression is controlled primarily by posttranscriptional processing, including changes in mRNA stability. However, the translational activity...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2009-12, Vol.297 (6), p.G1181-G1192
Hauptverfasser:	Kren, Betsy T, Wong, Phillip Y-P, Shiota, Akira, Zhang, Xiaoxiao, Zeng, Yan, Steer, Clifford J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Cell Proliferation Gene expression Gene Expression Profiling - methods Hepatectomy Liver Liver - metabolism Liver - pathology Liver - surgery Liver and Biliary Tract Liver Regeneration - genetics Male MicroRNAs - metabolism Models, Animal Oligonucleotide Array Sequence Analysis Polyribosomes - metabolism Proteins Proto-Oncogene Proteins c-myc - biosynthesis Proto-Oncogene Proteins c-myc - genetics Rats Rats, Sprague-Dawley Ribonucleic acid RNA RNA Processing, Post-Transcriptional RNA, Messenger - metabolism Rodents Time Factors Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - genetics
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