Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts

Intestinal injury following abdominal radiation therapy or accidental exposure remains a significant clinical problem that can result in varying degrees of mucosal destruction such as ulceration, vascular sclerosis, intestinal wall fibrosis, loss of barrier function, and even lethal gut-derived seps...

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Veröffentlicht in:	Am. J. Physiol. Gastrointest. Liver Physiol 2009-12, Vol.297 (6), p.G1041-G1052
Hauptverfasser:	Valuckaite, Vesta, Zaborina, Olga, Long, Jason, Hauer-Jensen, Martin, Wang, Junru, Holbrook, Christopher, Zaborin, Alexander, Drabik, Kenneth, Katdare, Mukta, Mauceri, Helena, Weichselbaum, Ralph, Firestone, Millicent A, Lee, Ka Yee, Chang, Eugene B, Matthews, Jeffrey, Alverdy, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals APOPTOSIS Apoptosis - drug effects Bacterial Adhesion - drug effects BASIC BIOLOGICAL SCIENCES Cell Line Cholesterol - metabolism COALESCENCE Copolymers Dose-Response Relationship, Drug FIBROSIS Human exposure Ileum - drug effects Ileum - microbiology Ileum - pathology Ileum - radiation effects INOCULATION Intestinal Diseases - metabolism Intestinal Diseases - pathology Intestinal Diseases - prevention & control Intestinal Mucosa - drug effects Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Intestinal Mucosa - radiation effects INTESTINES LIPIDS Male Membrane Microdomains - drug effects Membrane Microdomains - metabolism Membrane Microdomains - microbiology Membrane Microdomains - radiation effects MICE Mice, Inbred C57BL Molecular Weight MORTALITY PATHOGENS Polyethylene glycol Polyethylene Glycols - administration & dosage POLYETHYLENES PSEUDOMONAS Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - pathogenicity Radiation Injuries, Experimental - microbiology Radiation Injuries, Experimental - pathology Radiation Injuries, Experimental - prevention & control Radiation therapy Radiation-Protective Agents - administration & dosage RADIATIONS Rats Rats, Sprague-Dawley Sepsis Sepsis - microbiology Sepsis - prevention & control THERAPY Time Factors Translational Physiology Virulence - drug effects
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