Structural differences determine the relative selectivity of nicotinic compounds for native α4β2-, α6β2-, α3β4- and α7-nicotine acetylcholine receptors

Mammalian brain expresses multiple nicotinic acetylcholine receptor (nAChR) subtypes that differ in subunit composition, sites of expression and pharmacological and functional properties. Among known subtypes of receptors, α4β2* and α6β2*-nAChR have the highest affinity for nicotine (where * indicat...

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Veröffentlicht in:	Neuropharmacology 2010-06, Vol.58 (7), p.1054-1066
Hauptverfasser:	Grady, Sharon R., Drenan, Ryan M., Breining, Scott R., Yohannes, Daniel, Wageman, Charles R., Fedorov, Nikolai B., McKinney, Sheri, Whiteaker, Paul, Bencherif, Merouane, Lester, Henry A., Marks, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	TC1698 TC2242 TC2403 TC2429 TC6951 Varenicline
Online-Zugang:	Volltext
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