Enzyme-Catalyzed Transfer of a Ketone Group from an S-Adenosylmethionine Analogue: A Tool for the Functional Analysis of Methyltransferases

S-Adenosylmethionine (AdoMet or SAM)-dependent methyltransferases belong to a large and diverse family of group-transfer enzymes that perform vital biological functions on a host of substrates. Despite the progress in genomics, structural proteomics, and computational biology, functional annotation...

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Veröffentlicht in:	Journal of the American Chemical Society 2010-03, Vol.132 (11), p.3642-3643
Hauptverfasser:	Lee, Bobby W.K, Sun, He G, Zang, Tianzhu, Kim, Byung Ju, Alfaro, Joshua F, Zhou, Zhaohui Sunny
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocatalysis Enzyme Assays - methods Humans Hydrazines - chemistry Hydroxylamines - chemistry Ketones - chemistry Ketones - metabolism Methyltransferases - metabolism S-Adenosylmethionine - analogs & derivatives S-Adenosylmethionine - chemistry S-Adenosylmethionine - metabolism Substrate Specificity
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