Parallel Multiplicative Target Screening against Divergent Bacterial Replicases: Identification of Specific Inhibitors with Broad Spectrum Potential

Typically, biochemical screens that employ pure macromolecular components focus on single targets or a small number of interacting components. Researches rely on whole cell screens for more complex systems. Bacterial DNA replicases contain multiple subunits that change interactions with each stage o...

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Veröffentlicht in:	Biochemistry (Easton) 2010-03, Vol.49 (11), p.2551-2562
Hauptverfasser:	Dallmann, H. Garry, Fackelmayer, Oliver J, Tomer, Guy, Chen, Joe, Wiktor-Becker, Anna, Ferrara, Tracey, Pope, Casey, Oliveira, Marcos T, Burgers, Peter M. J, Kaguni, Laurie S, McHenry, Charles S
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacteria - enzymology DNA Replication - drug effects DNA, Bacterial - biosynthesis DNA-Directed DNA Polymerase Drug Evaluation, Preclinical - methods Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology High-Throughput Screening Assays Humans Nucleic Acid Synthesis Inhibitors Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Substrate Specificity
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