Vascular Endothelial Growth Factor Secreted by Activated Stroma Enhances Angiogenesis and Hormone-Independent Growth of Estrogen Receptor-Positive Breast Cancer

"Reactive" or activated stroma characterizes many malignancies including breast cancers. Recently, we isolated a reactive mouse mammary gland stromal cell line called BJ3Z. These cells express alpha-smooth muscle actin and stromal cell-derived factor 1 (SDF-1) and are tumorigenic when inje...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-04, Vol.70 (7), p.2655-2664
Hauptverfasser:	PINTO, Mauricio P, BADTKE, Melanie M, DUDEVOIR, Michelle L, HARRELL, J. Chuck, JACOBSEN, Britta M, HORWITZ, Kathryn B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Breast Neoplasms - blood supply Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Growth Processes - physiology Cell Line, Tumor Chemokine CXCL12 - biosynthesis Epithelial Cells - pathology Female Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Mice Neoplasms, Hormone-Dependent - blood supply Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Pharmacology. Drug treatments Receptors, Estrogen - biosynthesis Stromal Cells - metabolism Stromal Cells - pathology Tumor Necrosis Factor Ligand Superfamily Member 15 - metabolism Tumors
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