Cytosolic phospholipase a2 activation by Candida albicans in alveolar macrophages: role of dectin-1

Candida albicans is an increasingly important pulmonary fungal pathogen. Resident alveolar macrophages are important in host defense against opportunistic fungal infections. Activation of Group IVA cytosolic phospholipase A(2)alpha (cPLA(2)alpha) in macrophages initiates arachidonic acid (AA) releas...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2010-04, Vol.42 (4), p.415-423
Hauptverfasser:	Parti, Rajinder P, Loper, Robyn, Brown, Gordon D, Gordon, Siamon, Taylor, Philip R, Bonventre, Joseph V, Murphy, Robert C, Williams, David L, Leslie, Christina C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid - immunology Arachidonic Acid - metabolism Candida albicans - immunology Candidiasis - enzymology Candidiasis - genetics Candidiasis - immunology Enzyme Activation - drug effects Enzyme Activation - genetics Enzyme Activation - immunology Granulocyte-Macrophage Colony-Stimulating Factor - immunology Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Group IV Phospholipases A2 - immunology Group IV Phospholipases A2 - metabolism Intracellular Signaling Peptides and Proteins - immunology Intracellular Signaling Peptides and Proteins - metabolism Lectins, C-Type Macrophages, Alveolar - enzymology Macrophages, Alveolar - immunology MAP Kinase Kinase 1 - immunology MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - genetics MAP Kinase Signaling System - immunology Membrane Proteins - genetics Membrane Proteins - immunology Membrane Proteins - metabolism Mice Mice, Inbred BALB C Mice, Inbred ICR Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - immunology Nerve Tissue Proteins - metabolism Phosphorylation - drug effects Phosphorylation - genetics Phosphorylation - immunology Protein Kinase Inhibitors - pharmacology Protein-Tyrosine Kinases - immunology Protein-Tyrosine Kinases - metabolism Syk Kinase Time Factors Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism
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