TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN

On recognition of influenza virus (Flu) by TLR7, plasmacytoid dendritic cells (pDCs) produce type I IFN in significant amounts. Synthetic TLR7 ligands induce the maturation of pDCs, as evidenced by the expression of costimulatory molecules and the production of proinflammatory cytokines; however, th...

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Veröffentlicht in:	Blood 2009-08, Vol.114 (9), p.1794-1802
Hauptverfasser:	Di Domizio, Jérémy, Blum, Ariane, Gallagher-Gambarelli, Maighread, Molens, Jean-Paul, Chaperot, Laurence, Plumas, Joël
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Cell Differentiation Cell Line Cell Nucleus Cell Nucleus - metabolism Dendritic Cells Dendritic Cells - cytology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Immunology Inflammation Interferon Type I Interferon Type I - metabolism Interferons Interferons - metabolism Leukocytes, Mononuclear Leukocytes, Mononuclear - cytology Life Sciences Ligands Models, Biological Phosphorylation Signal Transduction Toll-Like Receptor 7 Toll-Like Receptor 7 - metabolism
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