Pigment Epithelium-Derived Factor Stimulates Tumor Macrophage Recruitment and Is Downregulated by the Prostate Tumor Microenvironment

Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis but whether it has additional effects on the tumor microenvironment is largely unexplored. We show that overexpression of PEDF in orthotopic MatLyLu rat prostate tumors increased tumor macrophage recruitment. The fraction...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neoplasia (New York, N.Y.) N.Y.), 2010-04, Vol.12 (4), p.336-345
Hauptverfasser:	Halin, Sofia, Rudolfsson, Stina Häggström, Doll, Jennifer A., Crawford, Susan E., Wikström, Pernilla, Bergh, Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma - genetics Carcinoma - immunology Carcinoma - metabolism Carcinoma - pathology Cell Movement - genetics Cell Proliferation Cytokines - genetics Cytokines - metabolism Down-Regulation Eye Proteins - genetics Eye Proteins - physiology Gene Expression Regulation, Neoplastic - drug effects Lymphatic Metastasis Macrophages - metabolism Macrophages - pathology Macrophages - physiology Male MEDICIN MEDICINE Neoplasm Transplantation Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Nerve Growth Factors - genetics Nerve Growth Factors - physiology Prostatic Neoplasms - genetics Prostatic Neoplasms - immunology Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Rats Serpins - genetics Serpins - physiology Transfection Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!