Redox-Mediated Reciprocal Regulation of SERCA and Na+/Ca2+-Exchanger Contributes to SR Ca2+-Depletion in Cardiac Myocytes

Myocardial failure is associated with increased oxidative stress and abnormal excitation-contraction coupling characterized by depletion of sarcoplasmic reticulum (SR) Ca 2+ -stores and a reduction in Ca 2+ -transient amplitude. Little is known about the mechanisms whereby oxidative stress affects C...

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Veröffentlicht in:	Free radical biology & medicine 2010-02, Vol.48 (9), p.1182-1187
Hauptverfasser:	Kuster, Gabriela M., Lancel, Steve, Zhang, Jingmei, Communal, Catherine, Trucillo, Mario P., Lim, Chee C., Pfister, Otmar, Weinberg, Ellen O., Cohen, Richard A., Liao, Ronglih, Siwik, Deborah A., Colucci, Wilson S.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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