Regulation of Synaptic Pumilio Function by an Aggregation-Prone Domain

We identified Pumilio (Pum), a Drosophila translational repressor, in a computational search for metazoan proteins whose activities might be regulated by assembly into ordered aggregates. The search algorithm was based on evolutionary sequence conservation patterns observed for yeast prion proteins,...

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Veröffentlicht in:	The Journal of neuroscience 2010-01, Vol.30 (2), p.515-522
Hauptverfasser:	Salazar, Anna M, Silverman, Edward J, Menon, Kaushiki P, Zinn, Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - metabolism Amyloid - ultrastructure Animals Animals, Genetically Modified Asparagine - metabolism Base Sequence Computational Biology Drosophila Drosophila Proteins - genetics Drosophila Proteins - metabolism Fungal Proteins - genetics Fungal Proteins - metabolism Gene Expression Regulation - physiology Gene Expression Regulation, Fungal Glutamine - metabolism Green Fluorescent Proteins - genetics Larva Luminescent Proteins - genetics Microscopy, Electron, Transmission - methods Molecular Sequence Data Muscles - metabolism Neuromuscular Junction - cytology Neuromuscular Junction - physiology Presynaptic Terminals - metabolism Presynaptic Terminals - ultrastructure Protein Binding - physiology Receptors, AMPA - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Sequence Homology, Amino Acid
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