Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options

Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disea...

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Veröffentlicht in:	European journal of neurology 2009-03, Vol.16 (3), p.297-309
Hauptverfasser:	Ludolph, A. C., Kassubek, J., Landwehrmeyer, B. G., Mandelkow, E., Mandelkow, E.-M., Burn, D. J., Caparros-Lefebvre, D., Frey, K. A., De Yebenes, J. G., Gasser, T., Heutink, P., Höglinger, G., Jamrozik, Z., Jellinger, K. A., Kazantsev, A., Kretzschmar, H., Lang, A. E., Litvan, I., Lucas, J. J., McGeer, P. L., Melquist, S., Oertel, W., Otto, M., Paviour, D., Reum, T., Saint-Raymond, A., Steele, J. C., Tolnay, M., Tumani, H., Van Swieten, J. C., Vanier, M. T., Vonsattel, J.-P., Wagner, S., Wszolek, Z. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers corticobasal degeneration Dementia - complications Dementia - genetics Dementia - physiopathology Drug Design frontotemporal dementia with parkinsonism linked to chromosome 17 Geography Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 microtubule-associated protein tau Models, Biological multiple system atrophy Mutation Niemann-Pick Disease, Type C - complications Niemann-Pick Disease, Type C - diagnosis Niemann-Pick Disease, Type C - physiopathology Parkinson disease Parkinson Disease, Postencephalitic - complications Parkinson Disease, Postencephalitic - physiopathology Parkinsonian Disorders - complications Parkinsonian Disorders - pathology Parkinsonian Disorders - physiopathology Parkinsonian Disorders - therapy parkinsonism Pick Disease of the Brain - complications Pick Disease of the Brain - pathology progressive supranuclear palsy Protein-Serine-Threonine Kinases - genetics Review Supranuclear Palsy, Progressive - complications Supranuclear Palsy, Progressive - diagnosis Supranuclear Palsy, Progressive - physiopathology tau Proteins - genetics tauopathies Tauopathies - complications Tauopathies - pathology Tauopathies - physiopathology Tauopathies - therapy
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