Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects
We used a previously validated automated machine learning algorithm based on adaptive boosting to segment the hippocampi in baseline and 12-month follow-up 3D T1-weighted brain MRIs of 150 cognitively normal elderly (NC), 245 mild cognitive impairment (MCI) and 97 Dementia of the Alzheimer’s type (D...
Gespeichert in:
Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2010-05, Vol.51 (1), p.488-499 |
---|---|
Hauptverfasser: | , , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 499 |
---|---|
container_issue | 1 |
container_start_page | 488 |
container_title | NeuroImage (Orlando, Fla.) |
container_volume | 51 |
creator | Apostolova, Liana G. Morra, Jonathan H. Green, Amity E. Hwang, Kristy S. Avedissian, Christina Woo, Ellen Cummings, Jeffrey L. Toga, Arthur W. Jack, Clifford R. Weiner, Michael W. Thompson, Paul M. |
description | We used a previously validated automated machine learning algorithm based on adaptive boosting to segment the hippocampi in baseline and 12-month follow-up 3D T1-weighted brain MRIs of 150 cognitively normal elderly (NC), 245 mild cognitive impairment (MCI) and 97 Dementia of the Alzheimer’s type (DAT) ADNI subjects. Using the radial distance mapping technique, we examined the hippocampal correlates of delayed recall performance on three well-established verbal memory tests—ADAScog delayed recall (ADAScog-DR), the Rey Auditory Verbal Learning Test -DR (AVLT-DR) and Wechsler Logical Memory II-DR (LM II-DR). We observed no significant correlations between delayed recall performance and hippocampal radial distance on any of the three verbal memory measures in NC. All three measures were associated with hippocampal volumes and radial distance in the full sample and in the MCI group at baseline and at follow-up. In DAT we observed stronger left-sided associations between hippocampal radial distance, LM II-DR and ADAScog-DR both at baseline and at follow-up. The strongest linkage between memory performance and hippocampal atrophy in the MCI sample was observed with the most challenging verbal memory test—the AVLT-DR, as opposed to the DAT sample where the least challenging test the ADAScog-DR showed strongest associations with the hippocampal structure. After controlling for baseline hippocampal atrophy, memory performance showed regionally specific associations with hippocampal radial distance in predominantly CA1 but also in subicular distribution. |
doi_str_mv | 10.1016/j.neuroimage.2009.12.125 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2847034</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1053811910000625</els_id><sourcerecordid>746302791</sourcerecordid><originalsourceid>FETCH-LOGICAL-c604t-7f03d078eb4d3c5b0637e4a78a7a8fc73f21c14b55a4bfdad7d96281fb727c603</originalsourceid><addsrcrecordid>eNqFkstu1DAUhiMEoqXwCsgSC1YZfEvsbJCGlkulCjawthznZOIosYPtTDXvwEPjYUq5bCpZOpbO9_-2j_-iQARvCCb1m3HjYA3eznoHG4pxsyE0r-pRcU5wU5VNJejj475ipSSkOSuexTjiDBIunxZnWSIZJeS8-LFdk591gg6xKzTrZbFuh3yPWh1hsg6Qdh0itJy9SwPSMXpjdbLeRdRCugVwKA0BAO0htHpCM8w-HHLRcQ0Qf8kHuyze6HnJfZ2CX4YDsg7xBqPt1edrFNd2BJPi8-JJr6cIL-7qRfHtw_uvl5_Kmy8fry-3N6WpMU-l6DHrsJDQ8o6ZqsU1E8C1kFpo2RvBekoM4W1Vad72ne5E19RUkr4VVGQLdlG8PfkuaztDZ8CloCe1hDzQcFBeW_Vvx9lB7fxeUckFZjwbvL4zCP77CjGp2UYD06Qd-DUqwWuGqWjIwyRjNeeMHz1f_UeOfg0uz0GRCteSMUGbTMkTZYKPMUB_f2uC1TEbalR_sqGO2VCE5lVl6cu_X30v_B2GDLw7AZBnv7cQVDQWnIHOhvw9qvP24VN-Ao-U0dM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1506833729</pqid></control><display><type>article</type><title>Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>ProQuest Central UK/Ireland</source><creator>Apostolova, Liana G. ; Morra, Jonathan H. ; Green, Amity E. ; Hwang, Kristy S. ; Avedissian, Christina ; Woo, Ellen ; Cummings, Jeffrey L. ; Toga, Arthur W. ; Jack, Clifford R. ; Weiner, Michael W. ; Thompson, Paul M.</creator><creatorcontrib>Apostolova, Liana G. ; Morra, Jonathan H. ; Green, Amity E. ; Hwang, Kristy S. ; Avedissian, Christina ; Woo, Ellen ; Cummings, Jeffrey L. ; Toga, Arthur W. ; Jack, Clifford R. ; Weiner, Michael W. ; Thompson, Paul M. ; the Alzheimer's Disease Neuroimaging Initiative ; Alzheimer's Disease Neuroimaging Initiative</creatorcontrib><description>We used a previously validated automated machine learning algorithm based on adaptive boosting to segment the hippocampi in baseline and 12-month follow-up 3D T1-weighted brain MRIs of 150 cognitively normal elderly (NC), 245 mild cognitive impairment (MCI) and 97 Dementia of the Alzheimer’s type (DAT) ADNI subjects. Using the radial distance mapping technique, we examined the hippocampal correlates of delayed recall performance on three well-established verbal memory tests—ADAScog delayed recall (ADAScog-DR), the Rey Auditory Verbal Learning Test -DR (AVLT-DR) and Wechsler Logical Memory II-DR (LM II-DR). We observed no significant correlations between delayed recall performance and hippocampal radial distance on any of the three verbal memory measures in NC. All three measures were associated with hippocampal volumes and radial distance in the full sample and in the MCI group at baseline and at follow-up. In DAT we observed stronger left-sided associations between hippocampal radial distance, LM II-DR and ADAScog-DR both at baseline and at follow-up. The strongest linkage between memory performance and hippocampal atrophy in the MCI sample was observed with the most challenging verbal memory test—the AVLT-DR, as opposed to the DAT sample where the least challenging test the ADAScog-DR showed strongest associations with the hippocampal structure. After controlling for baseline hippocampal atrophy, memory performance showed regionally specific associations with hippocampal radial distance in predominantly CA1 but also in subicular distribution.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2009.12.125</identifier><identifier>PMID: 20083211</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Algorithms ; Alzheimer Disease - pathology ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Artificial Intelligence ; Atrophy ; Automation ; Biomarkers ; Brain Mapping - methods ; Clinical trials ; Cognition Disorders - pathology ; Cognition Disorders - physiopathology ; Dementia ; Education ; Female ; Functional Laterality ; Hippocampus - pathology ; Hippocampus - physiopathology ; Humans ; Imaging, Three-Dimensional - methods ; Magnetic Resonance Imaging - methods ; Male ; Medical imaging ; Memory ; Mental Recall - physiology ; Middle Aged ; Speech Perception - physiology ; Studies ; Time Factors</subject><ispartof>NeuroImage (Orlando, Fla.), 2010-05, Vol.51 (1), p.488-499</ispartof><rights>2009 Elsevier Inc.</rights><rights>Copyright (c) 2009 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited May 15, 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-7f03d078eb4d3c5b0637e4a78a7a8fc73f21c14b55a4bfdad7d96281fb727c603</citedby><cites>FETCH-LOGICAL-c604t-7f03d078eb4d3c5b0637e4a78a7a8fc73f21c14b55a4bfdad7d96281fb727c603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1506833729?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20083211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Apostolova, Liana G.</creatorcontrib><creatorcontrib>Morra, Jonathan H.</creatorcontrib><creatorcontrib>Green, Amity E.</creatorcontrib><creatorcontrib>Hwang, Kristy S.</creatorcontrib><creatorcontrib>Avedissian, Christina</creatorcontrib><creatorcontrib>Woo, Ellen</creatorcontrib><creatorcontrib>Cummings, Jeffrey L.</creatorcontrib><creatorcontrib>Toga, Arthur W.</creatorcontrib><creatorcontrib>Jack, Clifford R.</creatorcontrib><creatorcontrib>Weiner, Michael W.</creatorcontrib><creatorcontrib>Thompson, Paul M.</creatorcontrib><creatorcontrib>the Alzheimer's Disease Neuroimaging Initiative</creatorcontrib><creatorcontrib>Alzheimer's Disease Neuroimaging Initiative</creatorcontrib><title>Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>We used a previously validated automated machine learning algorithm based on adaptive boosting to segment the hippocampi in baseline and 12-month follow-up 3D T1-weighted brain MRIs of 150 cognitively normal elderly (NC), 245 mild cognitive impairment (MCI) and 97 Dementia of the Alzheimer’s type (DAT) ADNI subjects. Using the radial distance mapping technique, we examined the hippocampal correlates of delayed recall performance on three well-established verbal memory tests—ADAScog delayed recall (ADAScog-DR), the Rey Auditory Verbal Learning Test -DR (AVLT-DR) and Wechsler Logical Memory II-DR (LM II-DR). We observed no significant correlations between delayed recall performance and hippocampal radial distance on any of the three verbal memory measures in NC. All three measures were associated with hippocampal volumes and radial distance in the full sample and in the MCI group at baseline and at follow-up. In DAT we observed stronger left-sided associations between hippocampal radial distance, LM II-DR and ADAScog-DR both at baseline and at follow-up. The strongest linkage between memory performance and hippocampal atrophy in the MCI sample was observed with the most challenging verbal memory test—the AVLT-DR, as opposed to the DAT sample where the least challenging test the ADAScog-DR showed strongest associations with the hippocampal structure. After controlling for baseline hippocampal atrophy, memory performance showed regionally specific associations with hippocampal radial distance in predominantly CA1 but also in subicular distribution.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Algorithms</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer's disease</subject><subject>Artificial Intelligence</subject><subject>Atrophy</subject><subject>Automation</subject><subject>Biomarkers</subject><subject>Brain Mapping - methods</subject><subject>Clinical trials</subject><subject>Cognition Disorders - pathology</subject><subject>Cognition Disorders - physiopathology</subject><subject>Dementia</subject><subject>Education</subject><subject>Female</subject><subject>Functional Laterality</subject><subject>Hippocampus - pathology</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Memory</subject><subject>Mental Recall - physiology</subject><subject>Middle Aged</subject><subject>Speech Perception - physiology</subject><subject>Studies</subject><subject>Time Factors</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkstu1DAUhiMEoqXwCsgSC1YZfEvsbJCGlkulCjawthznZOIosYPtTDXvwEPjYUq5bCpZOpbO9_-2j_-iQARvCCb1m3HjYA3eznoHG4pxsyE0r-pRcU5wU5VNJejj475ipSSkOSuexTjiDBIunxZnWSIZJeS8-LFdk591gg6xKzTrZbFuh3yPWh1hsg6Qdh0itJy9SwPSMXpjdbLeRdRCugVwKA0BAO0htHpCM8w-HHLRcQ0Qf8kHuyze6HnJfZ2CX4YDsg7xBqPt1edrFNd2BJPi8-JJr6cIL-7qRfHtw_uvl5_Kmy8fry-3N6WpMU-l6DHrsJDQ8o6ZqsU1E8C1kFpo2RvBekoM4W1Vad72ne5E19RUkr4VVGQLdlG8PfkuaztDZ8CloCe1hDzQcFBeW_Vvx9lB7fxeUckFZjwbvL4zCP77CjGp2UYD06Qd-DUqwWuGqWjIwyRjNeeMHz1f_UeOfg0uz0GRCteSMUGbTMkTZYKPMUB_f2uC1TEbalR_sqGO2VCE5lVl6cu_X30v_B2GDLw7AZBnv7cQVDQWnIHOhvw9qvP24VN-Ao-U0dM</recordid><startdate>20100515</startdate><enddate>20100515</enddate><creator>Apostolova, Liana G.</creator><creator>Morra, Jonathan H.</creator><creator>Green, Amity E.</creator><creator>Hwang, Kristy S.</creator><creator>Avedissian, Christina</creator><creator>Woo, Ellen</creator><creator>Cummings, Jeffrey L.</creator><creator>Toga, Arthur W.</creator><creator>Jack, Clifford R.</creator><creator>Weiner, Michael W.</creator><creator>Thompson, Paul M.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope><scope>5PM</scope></search><sort><creationdate>20100515</creationdate><title>Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects</title><author>Apostolova, Liana G. ; Morra, Jonathan H. ; Green, Amity E. ; Hwang, Kristy S. ; Avedissian, Christina ; Woo, Ellen ; Cummings, Jeffrey L. ; Toga, Arthur W. ; Jack, Clifford R. ; Weiner, Michael W. ; Thompson, Paul M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c604t-7f03d078eb4d3c5b0637e4a78a7a8fc73f21c14b55a4bfdad7d96281fb727c603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Algorithms</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer's disease</topic><topic>Artificial Intelligence</topic><topic>Atrophy</topic><topic>Automation</topic><topic>Biomarkers</topic><topic>Brain Mapping - methods</topic><topic>Clinical trials</topic><topic>Cognition Disorders - pathology</topic><topic>Cognition Disorders - physiopathology</topic><topic>Dementia</topic><topic>Education</topic><topic>Female</topic><topic>Functional Laterality</topic><topic>Hippocampus - pathology</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Memory</topic><topic>Mental Recall - physiology</topic><topic>Middle Aged</topic><topic>Speech Perception - physiology</topic><topic>Studies</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Apostolova, Liana G.</creatorcontrib><creatorcontrib>Morra, Jonathan H.</creatorcontrib><creatorcontrib>Green, Amity E.</creatorcontrib><creatorcontrib>Hwang, Kristy S.</creatorcontrib><creatorcontrib>Avedissian, Christina</creatorcontrib><creatorcontrib>Woo, Ellen</creatorcontrib><creatorcontrib>Cummings, Jeffrey L.</creatorcontrib><creatorcontrib>Toga, Arthur W.</creatorcontrib><creatorcontrib>Jack, Clifford R.</creatorcontrib><creatorcontrib>Weiner, Michael W.</creatorcontrib><creatorcontrib>Thompson, Paul M.</creatorcontrib><creatorcontrib>the Alzheimer's Disease Neuroimaging Initiative</creatorcontrib><creatorcontrib>Alzheimer's Disease Neuroimaging Initiative</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Apostolova, Liana G.</au><au>Morra, Jonathan H.</au><au>Green, Amity E.</au><au>Hwang, Kristy S.</au><au>Avedissian, Christina</au><au>Woo, Ellen</au><au>Cummings, Jeffrey L.</au><au>Toga, Arthur W.</au><au>Jack, Clifford R.</au><au>Weiner, Michael W.</au><au>Thompson, Paul M.</au><aucorp>the Alzheimer's Disease Neuroimaging Initiative</aucorp><aucorp>Alzheimer's Disease Neuroimaging Initiative</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2010-05-15</date><risdate>2010</risdate><volume>51</volume><issue>1</issue><spage>488</spage><epage>499</epage><pages>488-499</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>We used a previously validated automated machine learning algorithm based on adaptive boosting to segment the hippocampi in baseline and 12-month follow-up 3D T1-weighted brain MRIs of 150 cognitively normal elderly (NC), 245 mild cognitive impairment (MCI) and 97 Dementia of the Alzheimer’s type (DAT) ADNI subjects. Using the radial distance mapping technique, we examined the hippocampal correlates of delayed recall performance on three well-established verbal memory tests—ADAScog delayed recall (ADAScog-DR), the Rey Auditory Verbal Learning Test -DR (AVLT-DR) and Wechsler Logical Memory II-DR (LM II-DR). We observed no significant correlations between delayed recall performance and hippocampal radial distance on any of the three verbal memory measures in NC. All three measures were associated with hippocampal volumes and radial distance in the full sample and in the MCI group at baseline and at follow-up. In DAT we observed stronger left-sided associations between hippocampal radial distance, LM II-DR and ADAScog-DR both at baseline and at follow-up. The strongest linkage between memory performance and hippocampal atrophy in the MCI sample was observed with the most challenging verbal memory test—the AVLT-DR, as opposed to the DAT sample where the least challenging test the ADAScog-DR showed strongest associations with the hippocampal structure. After controlling for baseline hippocampal atrophy, memory performance showed regionally specific associations with hippocampal radial distance in predominantly CA1 but also in subicular distribution.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>20083211</pmid><doi>10.1016/j.neuroimage.2009.12.125</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1053-8119 |
ispartof | NeuroImage (Orlando, Fla.), 2010-05, Vol.51 (1), p.488-499 |
issn | 1053-8119 1095-9572 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2847034 |
source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
subjects | Aged Aged, 80 and over Algorithms Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Artificial Intelligence Atrophy Automation Biomarkers Brain Mapping - methods Clinical trials Cognition Disorders - pathology Cognition Disorders - physiopathology Dementia Education Female Functional Laterality Hippocampus - pathology Hippocampus - physiopathology Humans Imaging, Three-Dimensional - methods Magnetic Resonance Imaging - methods Male Medical imaging Memory Mental Recall - physiology Middle Aged Speech Perception - physiology Studies Time Factors |
title | Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T20%3A55%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Automated%203D%20mapping%20of%20baseline%20and%2012-month%20associations%20between%20three%20verbal%20memory%20measures%20and%20hippocampal%20atrophy%20in%20490%20ADNI%20subjects&rft.jtitle=NeuroImage%20(Orlando,%20Fla.)&rft.au=Apostolova,%20Liana%20G.&rft.aucorp=the%20Alzheimer's%20Disease%20Neuroimaging%20Initiative&rft.date=2010-05-15&rft.volume=51&rft.issue=1&rft.spage=488&rft.epage=499&rft.pages=488-499&rft.issn=1053-8119&rft.eissn=1095-9572&rft_id=info:doi/10.1016/j.neuroimage.2009.12.125&rft_dat=%3Cproquest_pubme%3E746302791%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1506833729&rft_id=info:pmid/20083211&rft_els_id=S1053811910000625&rfr_iscdi=true |