ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo

The three human alleles of apolipoprotein E (APOE) differentially influence outcome after CNS injury and affect one's risk of developing Alzheimer's disease (AD). It remains unclear how ApoE isoforms contribute to various AD-related pathological changes (e.g., amyloid plaques and synaptic...

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Veröffentlicht in:	The Journal of neuroscience 2009-12, Vol.29 (48), p.15317-15322
Hauptverfasser:	Dumanis, Sonya B, Tesoriero, Joseph A, Babus, Lenard W, Nguyen, Madeline T, Trotter, Justin H, Ladu, Mary Jo, Weeber, Edwin J, Turner, R. Scott, Xu, Baoji, Rebeck, G. William, Hoe, Hyang-Sook
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Analysis of Variance Animals Apolipoprotein E2 - genetics Apolipoprotein E3 - genetics Apolipoprotein E4 - genetics Apolipoprotein E4 - physiology Brief Communications Cells, Cultured Cerebral Cortex - cytology Dendrites - physiology Dendrites - ultrastructure Dendritic Spines - physiology Dendritic Spines - ultrastructure Embryo, Mammalian Hippocampus - cytology Humans Mice Mice, Inbred C57BL Mice, Transgenic Neurons - cytology Neurons - physiology Protein Isoforms - genetics Rats Rats, Sprague-Dawley Silver Staining - methods
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