The unfolded protein response signals through high-order assembly of Ire1

Aberrant folding of proteins in the endoplasmic reticulum activates the bifunctional transmembrane kinase/endoribonuclease Ire1. Ire1 excises an intron from HAC1 messenger RNA in yeasts and Xbp1 messenger RNA in metozoans encoding homologous transcription factors. This non-conventional mRNA splicing...

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Veröffentlicht in:	Nature 2009-02, Vol.457 (7230), p.687-693
Hauptverfasser:	Shokat, Kevan M, Finer-Moore, Janet, Korostelev, Andrei A, Zhang, Chao, Stroud, Robert M, Korennykh, Alexei V, Egea, Pascal F, Walter, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Basic-Leucine Zipper Transcription Factors - genetics Binding Sites Biological and medical sciences Cellular proteins Crystalline structure Crystallography, X-Ray Cytosol - metabolism Data collection E coli Endoplasmic reticulum Enzyme Activation - drug effects Enzymes Fundamental and applied biological sciences. Psychology Genetic aspects Humanities and Social Sciences Introns - genetics Kinases Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Models, Molecular Molecular biophysics multidisciplinary Phosphorylation - drug effects Physiological aspects Protein Binding - drug effects Protein Denaturation Protein Folding Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - metabolism Protein Kinase Inhibitors - pharmacology Protein Multimerization Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - chemistry Protein Serine-Threonine Kinases - metabolism Protein Structure, Quaternary Protein Structure, Tertiary Repressor Proteins - genetics Ribonucleases - chemistry Ribonucleases - metabolism RNA polymerase Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae Proteins - antagonists & inhibitors Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Science Science (multidisciplinary) Signal transduction Structure in molecular biology Yeasts
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